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Genetic dissociation of morphine analgesia from hyperalgesia in mice.
Marrone GF, Le Rouzic V, Varadi A, Xu J, Rajadhyaksha AM, Majumdar S, Pan YX, Pasternak GW. Marrone GF, et al. Among authors: rajadhyaksha am. Psychopharmacology (Berl). 2017 Jun;234(12):1891-1900. doi: 10.1007/s00213-017-4600-2. Epub 2017 Mar 25. Psychopharmacology (Berl). 2017. PMID: 28343361 Free PMC article.
Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.
Xu J, Lu Z, Narayan A, Le Rouzic VP, Xu M, Hunkele A, Brown TG, Hoefer WF, Rossi GC, Rice RC, Martínez-Rivera A, Rajadhyaksha AM, Cartegni L, Bassoni DL, Pasternak GW, Pan YX. Xu J, et al. Among authors: rajadhyaksha am. J Clin Invest. 2017 Apr 3;127(4):1561-1573. doi: 10.1172/JCI88760. Epub 2017 Mar 20. J Clin Invest. 2017. PMID: 28319053 Free PMC article.
Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia.
Martínez-Rivera A, Fetcho RN, Birmingham L, Xu J, Yang R, Foord C, Scala-Chávez D, Mekawy N, Pleil K, Pickel VM, Liston C, Castorena CM, Levitz J, Pan YX, Briand LA, Rajadhyaksha AM, Lee FS. Martínez-Rivera A, et al. Among authors: rajadhyaksha am. Sci Adv. 2024 Nov 29;10(48):eadq4779. doi: 10.1126/sciadv.adq4779. Epub 2024 Nov 29. Sci Adv. 2024. PMID: 39612328 Free PMC article.
Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels.
Schierberl K, Hao J, Tropea TF, Ra S, Giordano TP, Xu Q, Garraway SM, Hofmann F, Moosmang S, Striessnig J, Inturrisi CE, Rajadhyaksha AM. Schierberl K, et al. Among authors: rajadhyaksha am. J Neurosci. 2011 Sep 21;31(38):13562-75. doi: 10.1523/JNEUROSCI.2315-11.2011. J Neurosci. 2011. PMID: 21940447 Free PMC article.
83 results