Sun Z - Search Results

1

Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.

Sun Z, Zhang H, Chen Z, Xie Y, Jiang H, Chen L, Ding H, Zhang Y, Jiang H, Zheng M, Luo C. Sun Z, et al. Bioorg Med Chem Lett. 2017 May 1;27(9):2003-2009. doi: 10.1016/j.bmcl.2017.03.012. Epub 2017 Mar 9. Bioorg Med Chem Lett. 2017. PMID: 28347667

2

Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening.

Zhang FC, Sun ZY, Liao LP, Zuo Y, Zhang D, Wang J, Chen YT, Xiao SH, Jiang H, Lu T, Xu P, Yue LY, Du DH, Zhang H, Liu CP, Luo C. Zhang FC, et al. Acta Pharmacol Sin. 2020 Feb;41(2):286-292. doi: 10.1038/s41401-019-0256-2. Epub 2019 Jun 28. Acta Pharmacol Sin. 2020. PMID: 31253937 Free PMC article.

3

A Sphingosine-1-Phosphate Modulator Ameliorates Polycystic Kidney Disease in Han:SPRD Rats.

Li X, Wu M, Chen L, Lu J, Li G, Fu L, Qi N, Lin Y, Sun Z, Wang X, Zhang H, Liu J, Jiang H, Li L, Mei CL, Luo C. Li X, et al. Among authors: sun z. Am J Nephrol. 2020;51(1):1-10. doi: 10.1159/000502855. Epub 2019 Nov 6. Am J Nephrol. 2020. PMID: 31694015

4

Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain.

Chen Y, Bi X, Zhang F, Sun Z, Xu P, Jiang H, Lu W, Lu T, Ding H, Zhang N, Jiang H, Chen K, Zhou B, Luo C. Chen Y, et al. Among authors: sun z. Bioorg Chem. 2020 Aug;101:103991. doi: 10.1016/j.bioorg.2020.103991. Epub 2020 Jun 2. Bioorg Chem. 2020. PMID: 32559581

5

Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.

Sun Z, Zhang H, Zhang Y, Liao L, Zhou W, Zhang F, Lian F, Huang J, Xu P, Zhang R, Lu W, Zhu M, Tao H, Yang F, Ding H, Chen S, Yue L, Zhou B, Zhang N, Tan M, Jiang H, Chen K, Liu B, Liu C, Dang Y, Luo C. Sun Z, et al. Adv Sci (Weinh). 2020 May 13;7(14):2000098. doi: 10.1002/advs.202000098. eCollection 2020 Jul. Adv Sci (Weinh). 2020. PMID: 32714746 Free PMC article.

6

Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors.

Bi X, Chen Y, Sun Z, Lu W, Xu P, Lu T, Ding H, Zhang N, Jiang H, Chen K, Zhou B, Luo C. Bi X, et al. Among authors: sun z. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127480. doi: 10.1016/j.bmcl.2020.127480. Epub 2020 Aug 31. Bioorg Med Chem Lett. 2020. PMID: 32882416

7

Synthesis and structure-activity relationship studies of LLY-507 analogues as SMYD2 inhibitors.

Zhang B, Liao L, Wu F, Zhang F, Sun Z, Chen H, Luo C. Zhang B, et al. Among authors: sun z. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127598. doi: 10.1016/j.bmcl.2020.127598. Epub 2020 Oct 2. Bioorg Med Chem Lett. 2020. PMID: 33011288

8

Natural product 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase.

Li W, Liao LP, Song N, Liu YJ, Ding YL, Zhang YY, Zhou XR, Sun ZY, Xiao SH, Wang HB, Lu J, Zhang NX, Jiang HL, Chen KX, Liu CP, Zheng J, Zhao KH, Luo C. Li W, et al. Acta Pharmacol Sin. 2022 Feb;43(2):470-482. doi: 10.1038/s41401-021-00653-0. Epub 2021 Apr 13. Acta Pharmacol Sin. 2022. PMID: 33850276 Free PMC article.

9

The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay.

Wu Q, Sun Z, Chen Z, Liu J, Ding H, Luo C, Wang M, Du D. Wu Q, et al. Among authors: sun z. Bioorg Med Chem Lett. 2022 Oct 1;73:128883. doi: 10.1016/j.bmcl.2022.128883. Epub 2022 Jul 9. Bioorg Med Chem Lett. 2022. PMID: 35820623

10

A RhoA structure with switch II flipped outward revealed the conformational dynamics of switch II region.

Jiang H, Zu S, Lu Y, Sun Z, Adeerjiang A, Guo Q, Zhang H, Dong C, Wu Q, Ding H, Du D, Wang M, Liu C, Tang Y, Liang Z, Luo C. Jiang H, et al. Among authors: sun z. J Struct Biol. 2023 Jun;215(2):107942. doi: 10.1016/j.jsb.2023.107942. Epub 2023 Feb 11. J Struct Biol. 2023. PMID: 36781028

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