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Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice.
Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes AV, Wang Y, Burghardt TP, Szczesna-Cordary D. Yuan CC, et al. Among authors: irving tc. Cardiovasc Res. 2017 Aug 1;113(10):1124-1136. doi: 10.1093/cvr/cvx060. Cardiovasc Res. 2017. PMID: 28371863 Free PMC article.
Elastic proteins in the flight muscle of Manduca sexta.
Yuan CC, Ma W, Schemmel P, Cheng YS, Liu J, Tsaprailis G, Feldman S, Ayme Southgate A, Irving TC. Yuan CC, et al. Among authors: irving tc. Arch Biochem Biophys. 2015 Feb 15;568:16-27. doi: 10.1016/j.abb.2014.12.033. Epub 2015 Jan 17. Arch Biochem Biophys. 2015. PMID: 25602701 Free PMC article.
Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin.
Powers JD, Yuan CC, McCabe KJ, Murray JD, Childers MC, Flint GV, Moussavi-Harami F, Mohran S, Castillo R, Zuzek C, Ma W, Daggett V, McCulloch AD, Irving TC, Regnier M. Powers JD, et al. Among authors: irving tc. Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11502-11507. doi: 10.1073/pnas.1905028116. Epub 2019 May 20. Proc Natl Acad Sci U S A. 2019. PMID: 31110001 Free PMC article.
Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in Drosophila.
Trujillo AS, Hsu KH, Puthawala J, Viswanathan MC, Loya A, Irving TC, Cammarato A, Swank DM, Bernstein SI. Trujillo AS, et al. Among authors: irving tc. Mol Biol Cell. 2021 Aug 19;32(18):1690-1706. doi: 10.1091/mbc.E21-02-0088. Epub 2021 Jun 3. Mol Biol Cell. 2021. PMID: 34081531 Free PMC article.
194 results