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Page 1
Low frequency mutations in ribosomal proteins RPL10 and RPL5 in multiple myeloma.
Hofman IJF, Patchett S, van Duin M, Geerdens E, Verbeeck J, Michaux L, Delforge M, Sonneveld P, Johnson AW, De Keersmaecker K. Hofman IJF, et al. Among authors: de keersmaecker k. Haematologica. 2017 Aug;102(8):e317-e320. doi: 10.3324/haematol.2016.162198. Epub 2017 Apr 20. Haematologica. 2017. PMID: 28428269 Free PMC article. No abstract available.
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
Kalender Atak Z, De Keersmaecker K, Gianfelici V, Geerdens E, Vandepoel R, Pauwels D, Porcu M, Lahortiga I, Brys V, Dirks WG, Quentmeier H, Cloos J, Cuppens H, Uyttebroeck A, Vandenberghe P, Cools J, Aerts S. Kalender Atak Z, et al. Among authors: de keersmaecker k. PLoS One. 2012;7(6):e38463. doi: 10.1371/journal.pone.0038463. Epub 2012 Jun 4. PLoS One. 2012. PMID: 22675565 Free PMC article.
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.
De Keersmaecker K, Atak ZK, Li N, Vicente C, Patchett S, Girardi T, Gianfelici V, Geerdens E, Clappier E, Porcu M, Lahortiga I, Lucà R, Yan J, Hulselmans G, Vranckx H, Vandepoel R, Sweron B, Jacobs K, Mentens N, Wlodarska I, Cauwelier B, Cloos J, Soulier J, Uyttebroeck A, Bagni C, Hassan BA, Vandenberghe P, Johnson AW, Aerts S, Cools J. De Keersmaecker K, et al. Nat Genet. 2013 Feb;45(2):186-90. doi: 10.1038/ng.2508. Epub 2012 Dec 23. Nat Genet. 2013. PMID: 23263491 Free PMC article.
Comprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemia.
Atak ZK, Gianfelici V, Hulselmans G, De Keersmaecker K, Devasia AG, Geerdens E, Mentens N, Chiaretti S, Durinck K, Uyttebroeck A, Vandenberghe P, Wlodarska I, Cloos J, Foà R, Speleman F, Cools J, Aerts S. Atak ZK, et al. Among authors: de keersmaecker k. PLoS Genet. 2013;9(12):e1003997. doi: 10.1371/journal.pgen.1003997. Epub 2013 Dec 19. PLoS Genet. 2013. PMID: 24367274 Free PMC article.
Bypass of the pre-60S ribosomal quality control as a pathway to oncogenesis.
Sulima SO, Patchett S, Advani VM, De Keersmaecker K, Johnson AW, Dinman JD. Sulima SO, et al. Among authors: de keersmaecker k. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5640-5. doi: 10.1073/pnas.1400247111. Epub 2014 Mar 31. Proc Natl Acad Sci U S A. 2014. PMID: 24706786 Free PMC article.
RPL5 on 1p22.1 is recurrently deleted in multiple myeloma and its expression is linked to bortezomib response.
Hofman IJF, van Duin M, De Bruyne E, Fancello L, Mulligan G, Geerdens E, Garelli E, Mancini C, Lemmens H, Delforge M, Vandenberghe P, Wlodarska I, Aspesi A, Michaux L, Vanderkerken K, Sonneveld P, De Keersmaecker K. Hofman IJF, et al. Among authors: de bruyne e, de keersmaecker k. Leukemia. 2017 Aug;31(8):1706-1714. doi: 10.1038/leu.2016.370. Epub 2016 Dec 2. Leukemia. 2017. PMID: 27909306 Free PMC article.
The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.
Girardi T, Vereecke S, Sulima SO, Khan Y, Fancello L, Briggs JW, Schwab C, de Beeck JO, Verbeeck J, Royaert J, Geerdens E, Vicente C, Bornschein S, Harrison CJ, Meijerink JP, Cools J, Dinman JD, Kampen KR, De Keersmaecker K. Girardi T, et al. Among authors: de keersmaecker k, de beeck jo. Leukemia. 2018 Mar;32(3):809-819. doi: 10.1038/leu.2017.225. Epub 2017 Jul 24. Leukemia. 2018. PMID: 28744013 Free PMC article.
How Ribosomes Translate Cancer.
Sulima SO, Hofman IJF, De Keersmaecker K, Dinman JD. Sulima SO, et al. Among authors: de keersmaecker k. Cancer Discov. 2017 Oct;7(10):1069-1087. doi: 10.1158/2159-8290.CD-17-0550. Epub 2017 Sep 18. Cancer Discov. 2017. PMID: 28923911 Free PMC article. Review.
82 results