Funk C - Search Results

1

Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms.

Jaramillo CAC, Belli S, Cascais AC, Dudal S, Edelmann MR, Haak M, Brun ME, Otteneder MB, Ullah M, Funk C, Schuler F, Simon S. Jaramillo CAC, et al. Among authors: funk c. MAbs. 2017 Jul;9(5):781-791. doi: 10.1080/19420862.2017.1320008. Epub 2017 Apr 25. MAbs. 2017. PMID: 28440708 Free PMC article.

2

Calibration of in vitro multidrug resistance protein 1 substrate and inhibition assays as a basis to support the prediction of clinically relevant interactions in vivo.

Poirier A, Cascais AC, Bader U, Portmann R, Brun ME, Walter I, Hillebrecht A, Ullah M, Funk C. Poirier A, et al. Among authors: funk c. Drug Metab Dispos. 2014 Sep;42(9):1411-22. doi: 10.1124/dmd.114.057943. Epub 2014 Jun 17. Drug Metab Dispos. 2014. PMID: 24939652

3

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data.

Poirier A, Cascais AC, Funk C, Lavé T. Poirier A, et al. Among authors: funk c. J Pharmacokinet Pharmacodyn. 2009 Dec;36(6):585-611. doi: 10.1007/s10928-009-9139-3. Epub 2009 Nov 20. J Pharmacokinet Pharmacodyn. 2009. PMID: 19936896

4

Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies.

Poirier A, Belli S, Funk C, Otteneder MB, Portmann R, Heinig K, Prinssen E, Lazic SE, Rayner CR, Hoffmann G, Singer T, Smith DE, Schuler F. Poirier A, et al. Among authors: funk c. Drug Metab Dispos. 2012 Aug;40(8):1556-65. doi: 10.1124/dmd.112.044990. Epub 2012 May 14. Drug Metab Dispos. 2012. PMID: 22584254 Free PMC article.

5

The need for human breast cancer resistance protein substrate and inhibition evaluation in drug discovery and development: why, when, and how?

Poirier A, Portmann R, Cascais AC, Bader U, Walter I, Ullah M, Funk C. Poirier A, et al. Among authors: funk c. Drug Metab Dispos. 2014 Sep;42(9):1466-77. doi: 10.1124/dmd.114.058248. Epub 2014 Jul 2. Drug Metab Dispos. 2014. PMID: 24989889

6

Are Biotransformation Studies of Therapeutic Proteins Needed? Scientific Considerations and Technical Challenges.

Schadt S, Hauri S, Lopes F, Edelmann MR, Staack RF, Villaseñor R, Kettenberger H, Roth AB, Schuler F, Richter WF, Funk C. Schadt S, et al. Among authors: funk c. Drug Metab Dispos. 2019 Dec;47(12):1443-1456. doi: 10.1124/dmd.119.088997. Drug Metab Dispos. 2019. PMID: 31748266

7

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

Noé J, Portmann R, Brun ME, Funk C. Noé J, et al. Among authors: funk c. Drug Metab Dispos. 2007 Aug;35(8):1308-14. doi: 10.1124/dmd.106.012930. Epub 2007 Apr 30. Drug Metab Dispos. 2007. PMID: 17470528

8

Prediction of pharmacokinetic profile of valsartan in humans based on in vitro uptake-transport data.

Poirier A, Cascais AC, Funk C, Lavé T. Poirier A, et al. Among authors: funk c. Chem Biodivers. 2009 Nov;6(11):1975-87. doi: 10.1002/cbdv.200900116. Chem Biodivers. 2009. PMID: 19937834

9

PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation.

Caruso A, Alvarez-Sánchez R, Hillebrecht A, Poirier A, Schuler F, Lavé T, Funk C, Belli S. Caruso A, et al. Among authors: funk c. Biochem Pharmacol. 2013 Jun 1;85(11):1684-99. doi: 10.1016/j.bcp.2013.02.021. Epub 2013 Feb 27. Biochem Pharmacol. 2013. PMID: 23454189

10

Response to "Breast cancer resistance protein substrate and inhibition evaluation: why, when, and how?".

Poirier A, Ullah M, Funk C. Poirier A, et al. Among authors: funk c. Drug Metab Dispos. 2014 Dec;42(12):1981. doi: 10.1124/dmd.114.061465. Drug Metab Dispos. 2014. PMID: 25362072 No abstract available.

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