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591 results

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Page 1
Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function.
Yamazaki Y, Liu CC, Yamazaki A, Shue F, Martens YA, Chen Y, Qiao W, Kurti A, Oue H, Ren Y, Li Y, Aikawa T, Cherukuri Y, Fryer JD, Asmann YW, Kim BYS, Kanekiyo T, Bu G. Yamazaki Y, et al. Among authors: bu g. Neuron. 2021 Feb 3;109(3):438-447.e6. doi: 10.1016/j.neuron.2020.11.019. Epub 2020 Dec 14. Neuron. 2021. PMID: 33321072 Free PMC article.
Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function.
Liu CC, Zhao J, Fu Y, Inoue Y, Ren Y, Chen Y, Doss SV, Shue F, Jeevaratnam S, Bastea L, Wang N, Martens YA, Qiao W, Wang M, Zhao N, Jia L, Yamazaki Y, Yamazaki A, Rosenberg CL, Wang Z, Kong D, Li Z, Kuchenbecker LA, Trottier ZA, Felton L, Rogers J, Quicksall ZS, Linares C, Knight J, Chen Y, Kurti A, Kanekiyo T, Fryer JD, Asmann YW, Storz P, Wang X, Peng J, Zhang B, Kim BYS, Bu G. Liu CC, et al. Among authors: bu g. Nat Neurosci. 2022 Aug;25(8):1020-1033. doi: 10.1038/s41593-022-01127-0. Epub 2022 Aug 1. Nat Neurosci. 2022. PMID: 35915180 Free PMC article.
Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease.
Liu CC, Wang N, Chen Y, Inoue Y, Shue F, Ren Y, Wang M, Qiao W, Ikezu TC, Li Z, Zhao J, Martens Y, Doss SV, Rosenberg CL, Jeevaratnam S, Jia L, Raulin AC, Qi F, Zhu Y, Alnobani A, Knight J, Chen Y, Linares C, Kurti A, Fryer JD, Zhang B, Wu LJ, Kim BYS, Bu G. Liu CC, et al. Among authors: bu g. Nat Immunol. 2023 Nov;24(11):1854-1866. doi: 10.1038/s41590-023-01640-9. Epub 2023 Oct 19. Nat Immunol. 2023. PMID: 37857825
APOE ε2 is associated with increased tau pathology in primary tauopathy.
Zhao N, Liu CC, Van Ingelgom AJ, Linares C, Kurti A, Knight JA, Heckman MG, Diehl NN, Shinohara M, Martens YA, Attrebi ON, Petrucelli L, Fryer JD, Wszolek ZK, Graff-Radford NR, Caselli RJ, Sanchez-Contreras MY, Rademakers R, Murray ME, Koga S, Dickson DW, Ross OA, Bu G. Zhao N, et al. Among authors: bu g. Nat Commun. 2018 Oct 22;9(1):4388. doi: 10.1038/s41467-018-06783-0. Nat Commun. 2018. PMID: 30348994 Free PMC article.
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.
Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. Zhao Z, et al. Among authors: bu g. Nat Neurosci. 2015 Jul;18(7):978-87. doi: 10.1038/nn.4025. Epub 2015 May 25. Nat Neurosci. 2015. PMID: 26005850 Free PMC article.
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins.
Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, Perkerson EA, Yue M, Chew J, Castanedes-Casey M, Kurti A, Wang ZS, Liesinger AM, Baker JD, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Rademakers R, Boylan KB, Bu G, Link CD, Dickey CA, Rothstein JD, Dickson DW, Fryer JD, Petrucelli L. Zhang YJ, et al. Among authors: bu g. Nat Neurosci. 2016 May;19(5):668-677. doi: 10.1038/nn.4272. Epub 2016 Mar 21. Nat Neurosci. 2016. PMID: 26998601 Free PMC article.
Prosaposin is a regulator of progranulin levels and oligomerization.
Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, Fuchsberger C, Fowler S, Teslovich TM, Manning AK, Kumar S, Curran J, Lehman D, Abecasis G, Duggirala R, Pottier C, Zahir HA, Crook JE, Karydas A, Mitic L, Sun Y, Dickson DW, Bu G, Herz J, Yu G, Miller BL, Ferguson S, Petersen RC, Graff-Radford N, Blangero J, Rademakers R. Nicholson AM, et al. Among authors: bu g. Nat Commun. 2016 Jun 30;7:11992. doi: 10.1038/ncomms11992. Nat Commun. 2016. PMID: 27356620 Free PMC article.
Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, Younkin SG, Graff-Radford NR, Wszolek ZK, Brafman DA, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G. Zhao J, et al. Among authors: bu g. Nat Commun. 2021 May 5;12(1):2707. doi: 10.1038/s41467-021-23081-4. Nat Commun. 2021. PMID: 33953196 Free PMC article. No abstract available.
591 results