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DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy.
Chikamori K, Grozav AG, Kozuki T, Grabowski D, Ganapathi R, Ganapathi MK. Chikamori K, et al. Among authors: ganapathi r, ganapathi mk. Curr Cancer Drug Targets. 2010 Nov;10(7):758-71. doi: 10.2174/156800910793605785. Curr Cancer Drug Targets. 2010. PMID: 20578986 Review.
Phosphorylation of serine 1106 in the catalytic domain of topoisomerase II alpha regulates enzymatic activity and drug sensitivity.
Chikamori K, Grabowski DR, Kinter M, Willard BB, Yadav S, Aebersold RH, Bukowski RM, Hickson ID, Andersen AH, Ganapathi R, Ganapathi MK. Chikamori K, et al. Among authors: ganapathi r, ganapathi mk. J Biol Chem. 2003 Apr 11;278(15):12696-702. doi: 10.1074/jbc.M300837200. Epub 2003 Feb 4. J Biol Chem. 2003. PMID: 12569090 Free article.
Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin.
Vaziri SA, Hill J, Chikamori K, Grabowski DR, Takigawa N, Chawla-Sarkar M, Rybicki LR, Gudkov AV, Mekhail T, Bukowski RM, Ganapathi MK, Ganapathi R. Vaziri SA, et al. Among authors: ganapathi r, ganapathi mk. Mol Cancer Ther. 2005 Dec;4(12):1880-90. doi: 10.1158/1535-7163.MCT-05-0222. Mol Cancer Ther. 2005. PMID: 16373703
Tyrosine 656 in topoisomerase IIβ is important for the catalytic activity of the enzyme: Identification based on artifactual +80-Da modification at this site.
Grozav AG, Willard BB, Kozuki T, Chikamori K, Micluta MA, Petrescu AJ, Kinter M, Ganapathi R, Ganapathi MK. Grozav AG, et al. Among authors: ganapathi r, ganapathi mk. Proteomics. 2011 Mar;11(5):829-42. doi: 10.1002/pmic.201000194. Epub 2011 Jan 31. Proteomics. 2011. PMID: 21280220 Free PMC article.
58 results