Debets R - Search Results

1

The Sequence of Delta24-RGD and TMZ Administration in Malignant Glioma Affects the Role of CD8⁺T Cell Anti-tumor Activity.

Kleijn A, van den Bossche W, Haefner ES, Belcaid Z, Burghoorn-Maas C, Kloezeman JJ, Pas SD, Leenstra S, Debets R, de Vrij J, Dirven CMF, Lamfers MLM. Kleijn A, et al. Among authors: debets r. Mol Ther Oncolytics. 2017 Mar 1;5:11-19. doi: 10.1016/j.omto.2017.02.002. eCollection 2017 Jun 16. Mol Ther Oncolytics. 2017. PMID: 28480325 Free PMC article.

2

An oncolytic adenovirus redirected with a tumor-specific T-cell receptor.

Sebestyen Z, de Vrij J, Magnusson M, Debets R, Willemsen R. Sebestyen Z, et al. Among authors: debets r. Cancer Res. 2007 Dec 1;67(23):11309-16. doi: 10.1158/0008-5472.CAN-07-0739. Cancer Res. 2007. PMID: 18056457

3

The in vivo therapeutic efficacy of the oncolytic adenovirus Delta24-RGD is mediated by tumor-specific immunity.

Kleijn A, Kloezeman J, Treffers-Westerlaken E, Fulci G, Leenstra S, Dirven C, Debets R, Lamfers M. Kleijn A, et al. Among authors: debets r. PLoS One. 2014 May 27;9(5):e97495. doi: 10.1371/journal.pone.0097495. eCollection 2014. PLoS One. 2014. PMID: 24866126 Free PMC article.

4

Locally-delivered T-cell-derived cellular vehicles efficiently track and deliver adenovirus delta24-RGD to infiltrating glioma.

Balvers RK, Belcaid Z, van den Hengel SK, Kloezeman J, de Vrij J, Wakimoto H, Hoeben RC, Debets R, Leenstra S, Dirven C, Lamfers ML. Balvers RK, et al. Among authors: debets r. Viruses. 2014 Aug 12;6(8):3080-96. doi: 10.3390/v6083080. Viruses. 2014. PMID: 25118638 Free PMC article.

5

The therapeutic efficacy of the oncolytic virus Delta24-RGD in a murine glioma model depends primarily on antitumor immunity.

Kleijn A, Kloezeman J, Treffers-Westerlaken E, Fulci G, Leenstra S, Dirven C, Debets R, Lamfers M. Kleijn A, et al. Among authors: debets r. Oncoimmunology. 2014 Dec 13;3(9):e955697. doi: 10.4161/21624011.2014.955697. eCollection 2014 Oct. Oncoimmunology. 2014. PMID: 25941622 Free PMC article.

6

Low-dose oncolytic adenovirus therapy overcomes tumor-induced immune suppression and sensitizes intracranial gliomas to anti-PD-1 therapy.

Belcaid Z, Berrevoets C, Choi J, van Beelen E, Stavrakaki E, Pierson T, Kloezeman J, Routkevitch D, van der Kaaij M, van der Ploeg A, Mathios D, Sleijfer S, Dirven C, Lim M, Debets R, Lamfers MLM. Belcaid Z, et al. Among authors: debets r. Neurooncol Adv. 2020 Feb 3;2(1):vdaa011. doi: 10.1093/noajnl/vdaa011. eCollection 2020 Jan-Dec. Neurooncol Adv. 2020. PMID: 32642679 Free PMC article.

7

TCR gene-engineered T cell: limited T cell activation and combined use of IL-15 and IL-21 ensure minimal differentiation and maximal antigen-specificity.

Pouw N, Treffers-Westerlaken E, Mondino A, Lamers C, Debets R. Pouw N, et al. Among authors: debets r. Mol Immunol. 2010 Apr;47(7-8):1411-20. doi: 10.1016/j.molimm.2010.02.022. Mol Immunol. 2010. PMID: 20303179

8

T-cell receptor gene therapy in human melanoma-bearing immune-deficient mice: human but not mouse T cells recapitulate outcome of clinical studies.

Straetemans T, Coccoris M, Berrevoets C, Treffers-Westerlaken E, Scholten CE, Schipper D, Ten Hagen TL, Debets R. Straetemans T, et al. Among authors: debets r. Hum Gene Ther. 2012 Feb;23(2):187-201. doi: 10.1089/hum.2010.126. Epub 2011 Dec 2. Hum Gene Ther. 2012. PMID: 21958294

9

Recurrence of melanoma following T cell treatment: continued antigen expression in a tumor that evades T cell recruitment.

Straetemans T, Berrevoets C, Coccoris M, Treffers-Westerlaken E, Wijers R, Cole DK, Dardalhon V, Sewell AK, Taylor N, Verweij J, Debets R. Straetemans T, et al. Among authors: debets r. Mol Ther. 2015 Feb;23(2):396-406. doi: 10.1038/mt.2014.215. Epub 2014 Nov 3. Mol Ther. 2015. PMID: 25363716 Free PMC article.

10

Low-grade glioma harbors few CD8 T cells, which is accompanied by decreased expression of chemo-attractants, not immunogenic antigens.

Weenink B, Draaisma K, Ooi HZ, Kros JM, Sillevis Smitt PAE, Debets R, French PJ. Weenink B, et al. Among authors: debets r. Sci Rep. 2019 Oct 10;9(1):14643. doi: 10.1038/s41598-019-51063-6. Sci Rep. 2019. PMID: 31601888 Free PMC article.

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