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Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.
Nübling G, Schuberth M, Feldmer K, Giese A, Holdt LM, Teupser D, Lorenzl S. Nübling G, et al. Among authors: feldmer k. Exp Brain Res. 2017 Aug;235(8):2407-2412. doi: 10.1007/s00221-017-4978-4. Epub 2017 May 10. Exp Brain Res. 2017. PMID: 28493068