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p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.
Lam HC, Baglini CV, Lope AL, Parkhitko AA, Liu HJ, Alesi N, Malinowska IA, Ebrahimi-Fakhari D, Saffari A, Yu JJ, Pereira A, Khabibullin D, Ogorek B, Nijmeh J, Kavanagh T, Handen A, Chan SY, Asara JM, Oldham WM, Diaz-Meco MT, Moscat J, Sahin M, Priolo C, Henske EP. Lam HC, et al. Among authors: oldham wm. Cancer Res. 2017 Jun 15;77(12):3255-3267. doi: 10.1158/0008-5472.CAN-16-2458. Epub 2017 May 16. Cancer Res. 2017. PMID: 28512249 Free PMC article.
Branched chain α-ketoacids aerobically activate HIF1α signaling in vascular cells.
Xiao W, Shrimali N, Oldham WM, Clish CB, He H, Wong SJ, Wertheim BM, Arons E, Haigis MC, Leopold JA, Loscalzo J. Xiao W, et al. Among authors: oldham wm. bioRxiv [Preprint]. 2024 May 30:2024.05.29.595538. doi: 10.1101/2024.05.29.595538. bioRxiv. 2024. Update in: Nat Metab. 2024 Nov;6(11):2138-2156. doi: 10.1038/s42255-024-01150-4 PMID: 38853866 Free PMC article. Updated. Preprint.
Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis.
Ziehr DR, Li F, Parnell KM, Krah NM, Leahy KJ, Guillermier C, Varon J, Baron RM, Maron BA, Philp NJ, Hariri LP, Kim EY, Steinhauser ML, Knipe RS, Rutter J, Oldham WM. Ziehr DR, et al. Among authors: oldham wm. bioRxiv [Preprint]. 2024 Apr 28:2024.04.25.591150. doi: 10.1101/2024.04.25.591150. bioRxiv. 2024. PMID: 38712233 Free PMC article. Preprint.
Elevated Pulmonary Arterial Compliance Is Associated with Survival in Pulmonary Hypertension: Results from a Novel Network Medicine Analysis.
Wang RS, Huang S, Waldo SW, Hess E, Gokhale M, Johnson SW, Zeder K, Choudhary G, Leopold JA, Oldham WM, Kovacs G, Freiberg MS, Tedford RJ, Maron BA, Brittain EL. Wang RS, et al. Among authors: oldham wm. Am J Respir Crit Care Med. 2023 Aug 1;208(3):312-321. doi: 10.1164/rccm.202211-2097OC. Am J Respir Crit Care Med. 2023. PMID: 37276608 Free PMC article.
Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells.
Lam HC, Liu HJ, Baglini CV, Filippakis H, Alesi N, Nijmeh J, Du H, Lope AL, Cottrill KA, Handen A, Asara JM, Kwiatkowski DJ, Ben-Sahra I, Oldham WM, Chan SY, Henske EP. Lam HC, et al. Among authors: oldham wm. Oncotarget. 2017 Aug 4;8(39):64714-64727. doi: 10.18632/oncotarget.19947. eCollection 2017 Sep 12. Oncotarget. 2017. PMID: 29029388 Free PMC article.
[18F]Fluorocholine and [18F]Fluoroacetate PET as Imaging Biomarkers to Assess Phosphatidylcholine and Mitochondrial Metabolism in Preclinical Models of TSC and LAM.
Verwer EE, Kavanagh TR, Mischler WJ, Feng Y, Takahashi K, Wang S, Shoup TM, Neelamegam R, Yang J, Guehl NJ, Ran C, Massefski W, Cui Y, El-Chemaly S, Sadow PM, Oldham WM, Kijewski MF, El Fakhri G, Normandin MD, Priolo C. Verwer EE, et al. Among authors: oldham wm. Clin Cancer Res. 2018 Dec 1;24(23):5925-5938. doi: 10.1158/1078-0432.CCR-17-3693. Epub 2018 Jul 27. Clin Cancer Res. 2018. PMID: 30054282 Free PMC article.
Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.
Lam HC, Baglini CV, Lope AL, Parkhitko AA, Liu HJ, Alesi N, Malinowska IA, Ebrahimi-Fakhari D, Saffari A, Yu JJ, Pereira A, Khabibullin D, Ogorek B, Nijmeh J, Kavanagh T, Handen A, Chan SY, Asara JM, Oldham WM, Diaz-Meco MT, Moscat J, Sahin M, Priolo C, Henske EP. Lam HC, et al. Among authors: oldham wm. Cancer Res. 2020 Dec 1;80(23):5424. doi: 10.1158/0008-5472.CAN-20-3417. Cancer Res. 2020. PMID: 33268556 No abstract available.
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.
Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abélanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T. Torrino S, et al. Among authors: oldham wm. Cell Metab. 2021 Jul 6;33(7):1342-1357.e10. doi: 10.1016/j.cmet.2021.05.009. Epub 2021 Jun 7. Cell Metab. 2021. PMID: 34102109 Free article.
71 results