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The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
Bultynck G, Kiviluoto S, Henke N, Ivanova H, Schneider L, Rybalchenko V, Luyten T, Nuyts K, De Borggraeve W, Bezprozvanny I, Parys JB, De Smedt H, Missiaen L, Methner A. Bultynck G, et al. J Biol Chem. 2012 Jan 20;287(4):2544-57. doi: 10.1074/jbc.M111.275354. Epub 2011 Nov 28. J Biol Chem. 2012. PMID: 22128171 Free PMC article.
Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor.
Monaco G, Beckers M, Ivanova H, Missiaen L, Parys JB, De Smedt H, Bultynck G. Monaco G, et al. Among authors: bultynck g. Biochem Biophys Res Commun. 2012 Nov 9;428(1):31-5. doi: 10.1016/j.bbrc.2012.10.002. Epub 2012 Oct 8. Biochem Biophys Res Commun. 2012. PMID: 23058917
One interaction site for Bcl-2 was proposed in the central part of the modulatory domain [Y.P. Rong, A.S. Aromolaran, G. Bultynck, F. Zhong, X. Li, K. McColl, S. Matsuyama, S. Herlitze, H.L. Roderick, M.D. Bootman, G.A. Mignery, J.B. Parys, H. De Smedt, C.W. …
One interaction site for Bcl-2 was proposed in the central part of the modulatory domain [Y.P. Rong, A.S. Aromolaran, G. Bultynck
The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria.
Monaco G, Decrock E, Arbel N, van Vliet AR, La Rovere RM, De Smedt H, Parys JB, Agostinis P, Leybaert L, Shoshan-Barmatz V, Bultynck G. Monaco G, et al. Among authors: bultynck g. J Biol Chem. 2015 Apr 3;290(14):9150-61. doi: 10.1074/jbc.M114.622514. Epub 2015 Feb 13. J Biol Chem. 2015. PMID: 25681439 Free PMC article.
Antagonizing Bcl-2's BH4 domain in cancer.
Vervloessem T, La Rovere R, Bultynck G. Vervloessem T, et al. Among authors: bultynck g. Aging (Albany NY). 2015 Oct;7(10):748-9. doi: 10.18632/aging.100828. Aging (Albany NY). 2015. PMID: 26525307 Free PMC article. No abstract available.
256 results