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Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor.
Zhuang L, Tice CM, Xu Z, Zhao W, Cacatian S, Ye YJ, Singh SB, Lindblom P, McKeever BM, Krosky PM, Zhao Y, Lala D, Kruk BA, Meng S, Howard L, Johnson JA, Bukhtiyarov Y, Panemangalore R, Guo J, Guo R, Himmelsbach F, Hamilton B, Schuler-Metz A, Schauerte H, Gregg R, McGeehan GM, Leftheris K, Claremon DA. Zhuang L, et al. Among authors: hamilton b. Bioorg Med Chem. 2017 Jul 15;25(14):3649-3657. doi: 10.1016/j.bmc.2017.04.033. Epub 2017 Apr 29. Bioorg Med Chem. 2017. PMID: 28528082
Safety, pharmacokinetics and pharmacodynamics of BI 135585, a selective 11β-hydroxysteroid dehydrogenase-1 (HSD1) inhibitor in humans: liver and adipose tissue 11β-HSD1 inhibition after acute and multiple administrations over 2 weeks.
Freude S, Heise T, Woerle HJ, Jungnik A, Rauch T, Hamilton B, Schölch C, Huang F, Graefe-Mody U. Freude S, et al. Among authors: hamilton b. Diabetes Obes Metab. 2016 May;18(5):483-90. doi: 10.1111/dom.12635. Epub 2016 Mar 10. Diabetes Obes Metab. 2016. PMID: 26799632 Clinical Trial.
SGLT6 - A pharmacological target for the treatment of obesity?
Baader-Pagler T, Eckhardt M, Himmelsbach F, Sauer A, Stierstorfer BE, Hamilton BS. Baader-Pagler T, et al. Adipocyte. 2018;7(4):277-284. doi: 10.1080/21623945.2018.1516098. Epub 2018 Oct 11. Adipocyte. 2018. PMID: 30161013 Free PMC article.
Latent TGFβ-binding proteins regulate UCP1 expression and function via TGFβ2.
Halbgebauer D, Roos J, Funcke JB, Neubauer H, Hamilton BS, Simon E, Amri EZ, Debatin KM, Wabitsch M, Fischer-Posovszky P, Tews D. Halbgebauer D, et al. Among authors: hamilton bs. Mol Metab. 2021 Nov;53:101336. doi: 10.1016/j.molmet.2021.101336. Epub 2021 Sep 1. Mol Metab. 2021. PMID: 34481123 Free PMC article.
Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice.
Efthymiou V, Ding L, Balaz M, Sun W, Balazova L, Straub LG, Dong H, Simon E, Ghosh A, Perdikari A, Keller S, Ghoshdastider U, Horvath C, Moser C, Hamilton B, Neubauer H, Wolfrum C. Efthymiou V, et al. Among authors: hamilton b. Nat Commun. 2023 Jul 13;14(1):4162. doi: 10.1038/s41467-023-39715-8. Nat Commun. 2023. PMID: 37443109 Free PMC article.
1,557 results