Holt IJ - Search Results

1

ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.

Desai R, Frazier AE, Durigon R, Patel H, Jones AW, Dalla Rosa I, Lake NJ, Compton AG, Mountford HS, Tucker EJ, Mitchell ALR, Jackson D, Sesay A, Di Re M, van den Heuvel LP, Burke D, Francis D, Lunke S, McGillivray G, Mandelstam S, Mochel F, Keren B, Jardel C, Turner AM, Ian Andrews P, Smeitink J, Spelbrink JN, Heales SJ, Kohda M, Ohtake A, Murayama K, Okazaki Y, Lombès A, Holt IJ, Thorburn DR, Spinazzola A. Desai R, et al. Among authors: holt ij. Brain. 2017 Jun 1;140(6):1595-1610. doi: 10.1093/brain/awx094. Brain. 2017. PMID: 28549128 Free PMC article.

2

Mitochondrial myopathies: clinical and biochemical features of 30 patients with major deletions of muscle mitochondrial DNA.

Holt IJ, Harding AE, Cooper JM, Schapira AH, Toscano A, Clark JB, Morgan-Hughes JA. Holt IJ, et al. Ann Neurol. 1989 Dec;26(6):699-708. doi: 10.1002/ana.410260603. Ann Neurol. 1989. PMID: 2604380

3

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies.

Holt IJ, Harding AE, Morgan-Hughes JA. Holt IJ, et al. Nature. 1988 Feb 25;331(6158):717-9. doi: 10.1038/331717a0. Nature. 1988. PMID: 2830540

4

Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number.

Tyynismaa H, Sembongi H, Bokori-Brown M, Granycome C, Ashley N, Poulton J, Jalanko A, Spelbrink JN, Holt IJ, Suomalainen A. Tyynismaa H, et al. Among authors: holt ij. Hum Mol Genet. 2004 Dec 15;13(24):3219-27. doi: 10.1093/hmg/ddh342. Epub 2004 Oct 27. Hum Mol Genet. 2004. PMID: 15509589

5

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.

Pohjoismäki JL, Wanrooij S, Hyvärinen AK, Goffart S, Holt IJ, Spelbrink JN, Jacobs HT. Pohjoismäki JL, et al. Among authors: holt ij. Nucleic Acids Res. 2006;34(20):5815-28. doi: 10.1093/nar/gkl703. Epub 2006 Oct 24. Nucleic Acids Res. 2006. PMID: 17062618 Free PMC article.

6

The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization.

He J, Mao CC, Reyes A, Sembongi H, Di Re M, Granycome C, Clippingdale AB, Fearnley IM, Harbour M, Robinson AJ, Reichelt S, Spelbrink JN, Walker JE, Holt IJ. He J, et al. Among authors: holt ij. J Cell Biol. 2007 Jan 15;176(2):141-6. doi: 10.1083/jcb.200609158. Epub 2007 Jan 8. J Cell Biol. 2007. PMID: 17210950 Free PMC article.

7

The yeast Holliday junction resolvase, CCE1, can restore wild-type mitochondrial DNA to human cells carrying rearranged mitochondrial DNA.

Sembongi H, Di Re M, Bokori-Brown M, Holt IJ. Sembongi H, et al. Among authors: holt ij. Hum Mol Genet. 2007 Oct 1;16(19):2306-14. doi: 10.1093/hmg/ddm182. Epub 2007 Jul 31. Hum Mol Genet. 2007. PMID: 17666405

8

Mammalian mitochondrial nucleoids: organizing an independently minded genome.

Holt IJ, He J, Mao CC, Boyd-Kirkup JD, Martinsson P, Sembongi H, Reyes A, Spelbrink JN. Holt IJ, et al. Mitochondrion. 2007 Sep;7(5):311-21. doi: 10.1016/j.mito.2007.06.004. Epub 2007 Jul 4. Mitochondrion. 2007. PMID: 17698423 Review.

9

Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA.

Malena A, Loro E, Di Re M, Holt IJ, Vergani L. Malena A, et al. Among authors: holt ij. Hum Mol Genet. 2009 Sep 15;18(18):3407-16. doi: 10.1093/hmg/ddp281. Epub 2009 Jun 27. Hum Mol Genet. 2009. PMID: 19561330

10

The accessory subunit of mitochondrial DNA polymerase gamma determines the DNA content of mitochondrial nucleoids in human cultured cells.

Di Re M, Sembongi H, He J, Reyes A, Yasukawa T, Martinsson P, Bailey LJ, Goffart S, Boyd-Kirkup JD, Wong TS, Fersht AR, Spelbrink JN, Holt IJ. Di Re M, et al. Among authors: holt ij. Nucleic Acids Res. 2009 Sep;37(17):5701-13. doi: 10.1093/nar/gkp614. Epub 2009 Jul 22. Nucleic Acids Res. 2009. PMID: 19625489 Free PMC article.

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