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Targeting PAR1: Now What?
Flaumenhaft R, De Ceunynck K. Flaumenhaft R, et al. Trends Pharmacol Sci. 2017 Aug;38(8):701-716. doi: 10.1016/j.tips.2017.05.001. Epub 2017 May 27. Trends Pharmacol Sci. 2017. PMID: 28558960 Free PMC article. Review.
Protein disulfide isomerase as an antithrombotic target.
Flaumenhaft R. Flaumenhaft R. Trends Cardiovasc Med. 2013 Oct;23(7):264-8. doi: 10.1016/j.tcm.2013.03.001. Epub 2013 Mar 27. Trends Cardiovasc Med. 2013. PMID: 23541171 Free PMC article. Review.
PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.
De Ceunynck K, Peters CG, Jain A, Higgins SJ, Aisiku O, Fitch-Tewfik JL, Chaudhry SA, Dockendorff C, Parikh SM, Ingber DE, Flaumenhaft R. De Ceunynck K, et al. Among authors: flaumenhaft r. Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E982-E991. doi: 10.1073/pnas.1718600115. Epub 2018 Jan 17. Proc Natl Acad Sci U S A. 2018. PMID: 29343648 Free PMC article.
Tie2 protects the vasculature against thrombus formation in systemic inflammation.
Higgins SJ, De Ceunynck K, Kellum JA, Chen X, Gu X, Chaudhry SA, Schulman S, Libermann TA, Lu S, Shapiro NI, Christiani DC, Flaumenhaft R, Parikh SM. Higgins SJ, et al. Among authors: flaumenhaft r. J Clin Invest. 2018 Apr 2;128(4):1471-1484. doi: 10.1172/JCI97488. Epub 2018 Mar 5. J Clin Invest. 2018. PMID: 29360642 Free PMC article. Clinical Trial.
Protein disulfide isomerase regulation by nitric oxide maintains vascular quiescence and controls thrombus formation.
Bekendam RH, Iyu D, Passam F, Stopa JD, De Ceunynck K, Muse O, Bendapudi PK, Garnier CL, Gopal S, Crescence L, Chiu J, Furie B, Panicot-Dubois L, Hogg PJ, Dubois C, Flaumenhaft R. Bekendam RH, et al. Among authors: flaumenhaft r. J Thromb Haemost. 2018 Nov;16(11):2322-2335. doi: 10.1111/jth.14291. Epub 2018 Oct 12. J Thromb Haemost. 2018. PMID: 30207066 Free PMC article.
160 results