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Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling.
Satoh M, Nagasu H, Morita Y, Yamaguchi TP, Kanwar YS, Kashihara N. Satoh M, et al. Among authors: nagasu h. Am J Physiol Renal Physiol. 2012 Dec 15;303(12):F1641-51. doi: 10.1152/ajprenal.00460.2012. Epub 2012 Oct 3. Am J Physiol Renal Physiol. 2012. PMID: 23034937 Free PMC article.
Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function.
Nagasu H, Sogawa Y, Kidokoro K, Itano S, Yamamoto T, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Wigley WC, Proksch JW, Meyer CJ, Kashihara N. Nagasu H, et al. FASEB J. 2019 Nov;33(11):12253-12263. doi: 10.1096/fj.201900217R. Epub 2019 Aug 30. FASEB J. 2019. PMID: 31431054 Free PMC article.
Our data show that dh404 significantly reduced proteinuria-induced tubular cell mitochondrial damage, suggesting that improved redox balance and mitochondrial function and suppression of inflammation underlie the cytoprotective mechanism of Nrf2 activators, including bardoxolone …
Our data show that dh404 significantly reduced proteinuria-induced tubular cell mitochondrial damage, suggesting that improved redox balance …
63 results