Hintermann S - Search Results

1

Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.

Kallen J, Izaac A, Be C, Arista L, Orain D, Kaupmann K, Guntermann C, Hoegenauer K, Hintermann S. Kallen J, et al. Among authors: hintermann s. ChemMedChem. 2017 Jul 6;12(13):1014-1021. doi: 10.1002/cmdc.201700278. Epub 2017 Jun 20. ChemMedChem. 2017. PMID: 28590087

2

Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor.

Hintermann S, Hurth K, Nozulak J, Tintelnot-Blomley M, Aichholz R, Blanz J, Kaupmann K, Mosbacher J. Hintermann S, et al. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1523-6. doi: 10.1016/j.bmcl.2010.12.107. Epub 2010 Dec 28. Bioorg Med Chem Lett. 2011. PMID: 21277199

3

Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists.

Hintermann S, Guntermann C, Mattes H, Carcache DA, Wagner J, Vulpetti A, Billich A, Dawson J, Kaupmann K, Kallen J, Stringer R, Orain D. Hintermann S, et al. ChemMedChem. 2016 Dec 16;11(24):2640-2648. doi: 10.1002/cmdc.201600500. Epub 2016 Nov 30. ChemMedChem. 2016. PMID: 27902884

4

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.

Guntermann C, Piaia A, Hamel ML, Theil D, Rubic-Schneider T, Del Rio-Espinola A, Dong L, Billich A, Kaupmann K, Dawson J, Hoegenauer K, Orain D, Hintermann S, Stringer R, Patel DD, Doelemeyer A, Deurinck M, Schümann J. Guntermann C, et al. Among authors: hintermann s. JCI Insight. 2017 Mar 9;2(5):e91127. doi: 10.1172/jci.insight.91127. JCI Insight. 2017. PMID: 28289717 Free PMC article.

5

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.

Guendisch U, Weiss J, Ecoeur F, Riker JC, Kaupmann K, Kallen J, Hintermann S, Orain D, Dawson J, Billich A, Guntermann C. Guendisch U, et al. Among authors: hintermann s. PLoS One. 2017 Nov 20;12(11):e0188391. doi: 10.1371/journal.pone.0188391. eCollection 2017. PLoS One. 2017. PMID: 29155882 Free PMC article.

6

Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.

Carcache DA, Vulpetti A, Kallen J, Mattes H, Orain D, Stringer R, Vangrevelinghe E, Wolf RM, Kaupmann K, Ottl J, Dawson J, Cooke NG, Hoegenauer K, Billich A, Wagner J, Guntermann C, Hintermann S. Carcache DA, et al. Among authors: hintermann s. J Med Chem. 2018 Aug 9;61(15):6724-6735. doi: 10.1021/acs.jmedchem.8b00529. Epub 2018 Jul 24. J Med Chem. 2018. PMID: 29990434

7

Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses.

Ecoeur F, Weiss J, Kaupmann K, Hintermann S, Orain D, Guntermann C. Ecoeur F, et al. Among authors: hintermann s. Front Immunol. 2019 Mar 26;10:577. doi: 10.3389/fimmu.2019.00577. eCollection 2019. Front Immunol. 2019. PMID: 30972071 Free PMC article.

8

Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors.

Hoegenauer K, Kallen J, Jiménez-Núñez E, Strang R, Ertl P, Cooke NG, Hintermann S, Voegtle M, Betschart C, McKay DJJ, Wagner J, Ottl J, Beerli C, Billich A, Dawson J, Kaupmann K, Streiff M, Gobeau N, Harlfinger S, Stringer R, Guntermann C. Hoegenauer K, et al. Among authors: hintermann s. J Med Chem. 2019 Dec 12;62(23):10816-10832. doi: 10.1021/acs.jmedchem.9b01291. Epub 2019 Dec 3. J Med Chem. 2019. PMID: 31729873

9

Discovery, X-ray structure and CPP-conjugation enabled uptake of p53/MDM2 macrocyclic peptide inhibitors.

Schneider AFL, Kallen J, Ottl J, Reid PC, Ripoche S, Ruetz S, Stachyra TM, Hintermann S, Dumelin CE, Hackenberger CPR, Marzinzik AL. Schneider AFL, et al. Among authors: hintermann s. RSC Chem Biol. 2021 Aug 26;2(6):1661-1668. doi: 10.1039/d1cb00056j. eCollection 2021 Dec 2. RSC Chem Biol. 2021. PMID: 34977581 Free PMC article.

10

Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.

Montarolo F, Raffaele C, Perga S, Martire S, Finardi A, Furlan R, Hintermann S, Bertolotto A. Montarolo F, et al. Among authors: hintermann s. PLoS One. 2014 Sep 29;9(9):e108791. doi: 10.1371/journal.pone.0108791. eCollection 2014. PLoS One. 2014. PMID: 25265488 Free PMC article.

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