Finzel BC - Search Results

1

Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.

Liu F, Dawadi S, Maize KM, Dai R, Park SW, Schnappinger D, Finzel BC, Aldrich CC. Liu F, et al. Among authors: finzel bc. J Med Chem. 2017 Jul 13;60(13):5507-5520. doi: 10.1021/acs.jmedchem.7b00189. Epub 2017 Jun 22. J Med Chem. 2017. PMID: 28594172 Free PMC article.

2

Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.

Shi C, Geders TW, Park SW, Wilson DJ, Boshoff HI, Abayomi O, Barry CE 3rd, Schnappinger D, Finzel BC, Aldrich CC. Shi C, et al. Among authors: finzel bc. J Am Chem Soc. 2011 Nov 16;133(45):18194-201. doi: 10.1021/ja204036t. Epub 2011 Oct 24. J Am Chem Soc. 2011. PMID: 21988601 Free PMC article.

3

Bisubstrate adenylation inhibitors of biotin protein ligase from Mycobacterium tuberculosis.

Duckworth BP, Geders TW, Tiwari D, Boshoff HI, Sibbald PA, Barry CE 3rd, Schnappinger D, Finzel BC, Aldrich CC. Duckworth BP, et al. Among authors: finzel bc. Chem Biol. 2011 Nov 23;18(11):1432-41. doi: 10.1016/j.chembiol.2011.08.013. Chem Biol. 2011. PMID: 22118677 Free PMC article.

4

Inhibition of Mycobacterium tuberculosis transaminase BioA by aryl hydrazines and hydrazides.

Dai R, Wilson DJ, Geders TW, Aldrich CC, Finzel BC. Dai R, et al. Among authors: finzel bc. Chembiochem. 2014 Mar 3;15(4):575-86. doi: 10.1002/cbic.201300748. Epub 2014 Jan 31. Chembiochem. 2014. PMID: 24482078 Free PMC article.

5

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.

Park SW, Casalena DE, Wilson DJ, Dai R, Nag PP, Liu F, Boyce JP, Bittker JA, Schreiber SL, Finzel BC, Schnappinger D, Aldrich CC. Park SW, et al. Among authors: finzel bc. Chem Biol. 2015 Jan 22;22(1):76-86. doi: 10.1016/j.chembiol.2014.11.012. Epub 2014 Dec 31. Chem Biol. 2015. PMID: 25556942 Free PMC article.

6

Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.

Dai R, Geders TW, Liu F, Park SW, Schnappinger D, Aldrich CC, Finzel BC. Dai R, et al. Among authors: finzel bc. J Med Chem. 2015 Jul 9;58(13):5208-17. doi: 10.1021/acs.jmedchem.5b00092. Epub 2015 Jun 24. J Med Chem. 2015. PMID: 26068403 Free PMC article.

7

Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.

Bockman MR, Kalinda AS, Petrelli R, De la Mora-Rey T, Tiwari D, Liu F, Dawadi S, Nandakumar M, Rhee KY, Schnappinger D, Finzel BC, Aldrich CC. Bockman MR, et al. Among authors: finzel bc. J Med Chem. 2015 Sep 24;58(18):7349-7369. doi: 10.1021/acs.jmedchem.5b00719. Epub 2015 Sep 3. J Med Chem. 2015. PMID: 26299766 Free PMC article.

8

Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.

Kurbanov EK, Chiu TL, Solberg J, Francis S, Maize KM, Fernandez J, Johnson RL, Hawkinson JE, Walters MA, Finzel BC, Amin EA. Kurbanov EK, et al. Among authors: finzel bc. J Med Chem. 2015 Nov 12;58(21):8723-33. doi: 10.1021/acs.jmedchem.5b01446. Epub 2015 Oct 29. J Med Chem. 2015. PMID: 26492514

9

Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation.

Eiden CG, Maize KM, Finzel BC, Lipscomb JD, Aldrich CC. Eiden CG, et al. Among authors: finzel bc. J Am Chem Soc. 2017 May 31;139(21):7132-7135. doi: 10.1021/jacs.7b00962. Epub 2017 May 18. J Am Chem Soc. 2017. PMID: 28510452 Free PMC article.

10

Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.

Shah R, Strom A, Zhou A, Maize KM, Finzel BC, Wagner CR. Shah R, et al. Among authors: finzel bc. ACS Med Chem Lett. 2016 Jun 15;7(8):780-4. doi: 10.1021/acsmedchemlett.6b00169. eCollection 2016 Aug 11. ACS Med Chem Lett. 2016. PMID: 27563403 Free PMC article.

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