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A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action.
Campaner E, Rustighi A, Zannini A, Cristiani A, Piazza S, Ciani Y, Kalid O, Golan G, Baloglu E, Shacham S, Valsasina B, Cucchi U, Pippione AC, Lolli ML, Giabbai B, Storici P, Carloni P, Rossetti G, Benvenuti F, Bello E, D'Incalci M, Cappuzzello E, Rosato A, Del Sal G. Campaner E, et al. Among authors: ciani y. Nat Commun. 2017 Jun 9;8:15772. doi: 10.1038/ncomms15772. Nat Commun. 2017. PMID: 28598431 Free PMC article.
PIN1 in breast development and cancer: a clinical perspective.
Rustighi A, Zannini A, Campaner E, Ciani Y, Piazza S, Del Sal G. Rustighi A, et al. Among authors: ciani y. Cell Death Differ. 2017 Feb;24(2):200-211. doi: 10.1038/cdd.2016.122. Epub 2016 Nov 11. Cell Death Differ. 2017. PMID: 27834957 Free PMC article. Review.
Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer.
Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, Rajkowska K, Gaweda-Walerych K, Ingallina E, Tonelli C, Morelli MJ, Amato A, Eterno V, Zambelli A, Rosato A, Amati B, Wiśniewski JR, Del Sal G. Walerych D, et al. Among authors: ciani y. Nat Cell Biol. 2016 Aug;18(8):897-909. doi: 10.1038/ncb3380. Epub 2016 Jun 27. Nat Cell Biol. 2016. PMID: 27347849 Free article.
Effects of Pin1 Loss in Hdh(Q111) Knock-in Mice.
Agostoni E, Michelazzi S, Maurutto M, Carnemolla A, Ciani Y, Vatta P, Roncaglia P, Zucchelli S, Leanza G, Mantovani F, Gustincich S, Santoro C, Piazza S, Del Sal G, Persichetti F. Agostoni E, et al. Among authors: ciani y. Front Cell Neurosci. 2016 May 2;10:110. doi: 10.3389/fncel.2016.00110. eCollection 2016. Front Cell Neurosci. 2016. PMID: 27199664 Free PMC article.
A gene expression signature of retinoblastoma loss-of-function is a predictive biomarker of resistance to palbociclib in breast cancer cell lines and is prognostic in patients with ER positive early breast cancer.
Malorni L, Piazza S, Ciani Y, Guarducci C, Bonechi M, Biagioni C, Hart CD, Verardo R, Di Leo A, Migliaccio I. Malorni L, et al. Among authors: ciani y. Oncotarget. 2016 Sep 13;7(42):68012-68022. doi: 10.18632/oncotarget.12010. Oncotarget. 2016. PMID: 27634906 Free PMC article.
43 results