Rauh D - Search Results

1

Trisubstituted Pyridinylimidazoles as Potent Inhibitors of the Clinically Resistant L858R/T790M/C797S EGFR Mutant: Targeting of Both Hydrophobic Regions and the Phosphate Binding Site.

Günther M, Lategahn J, Juchum M, Döring E, Keul M, Engel J, Tumbrink HL, Rauh D, Laufer S. Günther M, et al. Among authors: rauh d. J Med Chem. 2017 Jul 13;60(13):5613-5637. doi: 10.1021/acs.jmedchem.7b00316. Epub 2017 Jun 21. J Med Chem. 2017. PMID: 28603991

2

Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.

Michalczyk A, Klüter S, Rode HB, Simard JR, Grütter C, Rabiller M, Rauh D. Michalczyk A, et al. Among authors: rauh d. Bioorg Med Chem. 2008 Apr 1;16(7):3482-8. doi: 10.1016/j.bmc.2008.02.053. Epub 2008 Feb 20. Bioorg Med Chem. 2008. PMID: 18316192

3

ATP competitive inhibitors of D-alanine-D-alanine ligase based on protein kinase inhibitor scaffolds.

Triola G, Wetzel S, Ellinger B, Koch MA, Hübel K, Rauh D, Waldmann H. Triola G, et al. Among authors: rauh d. Bioorg Med Chem. 2009 Feb 1;17(3):1079-87. doi: 10.1016/j.bmc.2008.02.046. Epub 2008 Feb 16. Bioorg Med Chem. 2009. PMID: 18321716

4

Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc.

Getlik M, Grütter C, Simard JR, Klüter S, Rabiller M, Rode HB, Robubi A, Rauh D. Getlik M, et al. Among authors: rauh d. J Med Chem. 2009 Jul 9;52(13):3915-26. doi: 10.1021/jm9002928. J Med Chem. 2009. PMID: 19462975

5

Displacement assay for the detection of stabilizers of inactive kinase conformations.

Klüter S, Grütter C, Naqvi T, Rabiller M, Simard JR, Pawar V, Getlik M, Rauh D. Klüter S, et al. Among authors: rauh d. J Med Chem. 2010 Jan 14;53(1):357-67. doi: 10.1021/jm901297e. J Med Chem. 2010. PMID: 19928858

6

Synthesis and biological evaluation of 4-anilinoquinolines as potent inhibitors of epidermal growth factor receptor.

Pawar VG, Sos ML, Rode HB, Rabiller M, Heynck S, van Otterlo WA, Thomas RK, Rauh D. Pawar VG, et al. Among authors: rauh d. J Med Chem. 2010 Apr 8;53(7):2892-901. doi: 10.1021/jm901877j. J Med Chem. 2010. PMID: 20222733

7

Characterization of irreversible kinase inhibitors by directly detecting covalent bond formation: a tool for dissecting kinase drug resistance.

Klüter S, Simard JR, Rode HB, Grütter C, Pawar V, Raaijmakers HC, Barf TA, Rabiller M, van Otterlo WA, Rauh D. Klüter S, et al. Among authors: rauh d. Chembiochem. 2010 Dec 10;11(18):2557-66. doi: 10.1002/cbic.201000352. Chembiochem. 2010. PMID: 21080395

8

Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor.

Rode HB, Sos ML, Grütter C, Heynck S, Simard JR, Rauh D. Rode HB, et al. Among authors: rauh d. Bioorg Med Chem. 2011 Jan 1;19(1):429-39. doi: 10.1016/j.bmc.2010.11.007. Epub 2010 Nov 10. Bioorg Med Chem. 2011. PMID: 21130659

9

Using small molecules to target protein phosphatases.

Vintonyak VV, Waldmann H, Rauh D. Vintonyak VV, et al. Among authors: rauh d. Bioorg Med Chem. 2011 Apr 1;19(7):2145-55. doi: 10.1016/j.bmc.2011.02.047. Epub 2011 Mar 2. Bioorg Med Chem. 2011. PMID: 21420867

10

Structure-based design, synthesis and biological evaluation of N-pyrazole, N'-thiazole urea inhibitors of MAP kinase p38α.

Getlik M, Grütter C, Simard JR, Nguyen HD, Robubi A, Aust B, van Otterlo WA, Rauh D. Getlik M, et al. Among authors: rauh d. Eur J Med Chem. 2012 Feb;48:1-15. doi: 10.1016/j.ejmech.2011.11.019. Epub 2011 Nov 18. Eur J Med Chem. 2012. PMID: 22154891

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