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New aspects of sphingosine 1-phosphate signaling in mammalian cells.
Pyne NJ, Long JS, Lee SC, Loveridge C, Gillies L, Pyne S. Pyne NJ, et al. Among authors: pyne s. Adv Enzyme Regul. 2009;49(1):214-21. doi: 10.1016/j.advenzreg.2009.01.011. Adv Enzyme Regul. 2009. PMID: 19534035 Review. No abstract available.
Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells.
Long JS, Edwards J, Watson C, Tovey S, Mair KM, Schiff R, Natarajan V, Pyne NJ, Pyne S. Long JS, et al. Among authors: pyne s, pyne nj. Mol Cell Biol. 2010 Aug;30(15):3827-41. doi: 10.1128/MCB.01133-09. Epub 2010 Jun 1. Mol Cell Biol. 2010. PMID: 20516217 Free PMC article.
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Tonelli F, Lim KG, Loveridge C, Long J, Pitson SM, Tigyi G, Bittman R, Pyne S, Pyne NJ. Tonelli F, et al. Among authors: pyne s, pyne nj. Cell Signal. 2010 Oct;22(10):1536-42. doi: 10.1016/j.cellsig.2010.05.022. Epub 2010 Jun 4. Cell Signal. 2010. PMID: 20570726 Free PMC article.
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
Loveridge C, Tonelli F, Leclercq T, Lim KG, Long JS, Berdyshev E, Tate RJ, Natarajan V, Pitson SM, Pyne NJ, Pyne S. Loveridge C, et al. Among authors: pyne s, pyne nj. J Biol Chem. 2010 Dec 10;285(50):38841-52. doi: 10.1074/jbc.M110.127993. Epub 2010 Oct 6. J Biol Chem. 2010. PMID: 20926375 Free PMC article.
428 results