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Biochemical mechanisms of the generation of endogenous long chain ceramide in response to exogenous short chain ceramide in the A549 human lung adenocarcinoma cell line. Role for endogenous ceramide in mediating the action of exogenous ceramide.
Ogretmen B, Pettus BJ, Rossi MJ, Wood R, Usta J, Szulc Z, Bielawska A, Obeid LM, Hannun YA. Ogretmen B, et al. J Biol Chem. 2002 Apr 12;277(15):12960-9. doi: 10.1074/jbc.M110699200. Epub 2002 Jan 28. J Biol Chem. 2002. PMID: 11815611 Free article.
Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitro and in vivo.
Senkal CE, Ponnusamy S, Rossi MJ, Sundararaj K, Szulc Z, Bielawski J, Bielawska A, Meyer M, Cobanoglu B, Koybasi S, Sinha D, Day TA, Obeid LM, Hannun YA, Ogretmen B. Senkal CE, et al. J Pharmacol Exp Ther. 2006 Jun;317(3):1188-99. doi: 10.1124/jpet.106.101949. Epub 2006 Mar 1. J Pharmacol Exp Ther. 2006. PMID: 16510697
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B. Sentelle RD, et al. Among authors: szulc zm. Nat Chem Biol. 2012 Oct;8(10):831-8. doi: 10.1038/nchembio.1059. Nat Chem Biol. 2012. PMID: 22922758 Free PMC article.
LCL124, a cationic analog of ceramide, selectively induces pancreatic cancer cell death by accumulating in mitochondria.
Beckham TH, Lu P, Jones EE, Marrison T, Lewis CS, Cheng JC, Ramshesh VK, Beeson G, Beeson CC, Drake RR, Bielawska A, Bielawski J, Szulc ZM, Ogretmen B, Norris JS, Liu X. Beckham TH, et al. Among authors: szulc zm. J Pharmacol Exp Ther. 2013 Jan;344(1):167-78. doi: 10.1124/jpet.112.199216. Epub 2012 Oct 18. J Pharmacol Exp Ther. 2013. PMID: 23086228 Free PMC article.
84 results