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Page 1
Discovery of a Series of Indazole TRPA1 Antagonists.
Pryde DC, Marron BE, West CW, Reister S, Amato G, Yoger K, Antonio B, Padilla K, Cox PJ, Turner J, Warmus JS, Swain NA, Omoto K, Mahoney JH, Gerlach AC. Pryde DC, et al. ACS Med Chem Lett. 2017 May 18;8(6):666-671. doi: 10.1021/acsmedchemlett.7b00140. eCollection 2017 Jun 8. ACS Med Chem Lett. 2017. PMID: 28626530 Free PMC article.
The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics.
Pryde DC, Swain NA, Stupple PA, West CW, Marron B, Markworth CJ, Printzenhoff D, Lin Z, Cox PJ, Suzuki R, McMurray S, Waldron GJ, Payne CE, Warmus JS, Chapman ML. Pryde DC, et al. Medchemcomm. 2017 Apr 28;8(6):1255-1267. doi: 10.1039/c7md00131b. eCollection 2017 Jun 1. Medchemcomm. 2017. PMID: 30108836 Free PMC article.
Ion channels as therapeutic targets: a drug discovery perspective.
Bagal SK, Brown AD, Cox PJ, Omoto K, Owen RM, Pryde DC, Sidders B, Skerratt SE, Stevens EB, Storer RI, Swain NA. Bagal SK, et al. Among authors: pryde dc. J Med Chem. 2013 Feb 14;56(3):593-624. doi: 10.1021/jm3011433. Epub 2012 Nov 29. J Med Chem. 2013. PMID: 23121096 Review.
TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype.
Tseng WC, Pryde DC, Yoger KE, Padilla KM, Antonio BM, Han S, Shanmugasundaram V, Gerlach AC. Tseng WC, et al. Among authors: pryde dc. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12301-12306. doi: 10.1073/pnas.1808142115. Epub 2018 Nov 14. Proc Natl Acad Sci U S A. 2018. PMID: 30429323 Free PMC article.
Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865).
Owen RM, Blakemore D, Cao L, Flanagan N, Fish R, Gibson KR, Gurrell R, Huh CW, Kammonen J, Mortimer-Cassen E, Nickolls SA, Omoto K, Owen D, Pike A, Pryde DC, Reynolds DS, Roeloffs R, Rose C, Stead C, Takeuchi M, Warmus JS, Watson C. Owen RM, et al. Among authors: pryde dc. J Med Chem. 2019 Jun 27;62(12):5773-5796. doi: 10.1021/acs.jmedchem.9b00322. Epub 2019 Apr 26. J Med Chem. 2019. PMID: 30964988
Corrigendum to "Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1" [Bioorg. Med. Chem. Lett. 26 (2016) 4919-4924].
Monteillier A, Loucif A, Omoto K, Stevens EB, Lainez S, Saintot PP, Cao L, Pryde DC. Monteillier A, et al. Among authors: pryde dc. Bioorg Med Chem Lett. 2017 May 1;27(9):2082. doi: 10.1016/j.bmcl.2017.02.063. Epub 2017 Mar 17. Bioorg Med Chem Lett. 2017. PMID: 28320618 No abstract available.
Medicinal chemistry approaches to avoid aldehyde oxidase metabolism.
Pryde DC, Tran TD, Jones P, Duckworth J, Howard M, Gardner I, Hyland R, Webster R, Wenham T, Bagal S, Omoto K, Schneider RP, Lin J. Pryde DC, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2856-60. doi: 10.1016/j.bmcl.2012.02.069. Epub 2012 Mar 3. Bioorg Med Chem Lett. 2012. PMID: 22429467
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