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Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques.
Broeckel R, Fox JM, Haese N, Kreklywich CN, Sukulpovi-Petty S, Legasse A, Smith PP, Denton M, Corvey C, Krishnan S, Colgin LMA, Ducore RM, Lewis AD, Axthelm MK, Mandron M, Cortez P, Rothblatt J, Rao E, Focken I, Carter K, Sapparapau G, Crowe JE Jr, Diamond MS, Streblow DN. Broeckel R, et al. PLoS Negl Trop Dis. 2017 Jun 19;11(6):e0005637. doi: 10.1371/journal.pntd.0005637. eCollection 2017 Jun. PLoS Negl Trop Dis. 2017. PMID: 28628616 Free PMC article.
Animal Models of Chikungunya Virus Infection and Disease.
Haese NN, Broeckel RM, Hawman DW, Heise MT, Morrison TE, Streblow DN. Haese NN, et al. J Infect Dis. 2016 Dec 15;214(suppl 5):S482-S487. doi: 10.1093/infdis/jiw284. J Infect Dis. 2016. PMID: 27920178 Free PMC article. Review.
Vaccine-Induced Skewing of T Cell Responses Protects Against Chikungunya Virus Disease.
Broeckel RM, Haese N, Ando T, Dmitriev I, Kreklywich CN, Powers J, Denton M, Smith P, Morrison TE, Heise M, DeFilippis V, Messaoudi I, Curiel DT, Streblow DN. Broeckel RM, et al. Front Immunol. 2019 Oct 31;10:2563. doi: 10.3389/fimmu.2019.02563. eCollection 2019. Front Immunol. 2019. PMID: 31736977 Free PMC article.
Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.
Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN. Hirsch AJ, et al. Among authors: broeckel rm. PLoS Pathog. 2017 Mar 9;13(3):e1006219. doi: 10.1371/journal.ppat.1006219. eCollection 2017 Mar. PLoS Pathog. 2017. PMID: 28278237 Free PMC article.
Non-replicating adenovirus based Mayaro virus vaccine elicits protective immune responses and cross protects against other alphaviruses.
Powers JM, Haese NN, Denton M, Ando T, Kreklywich C, Bonin K, Streblow CE, Kreklywich N, Smith P, Broeckel R, DeFilippis V, Morrison TE, Heise MT, Streblow DN. Powers JM, et al. Among authors: broeckel r. PLoS Negl Trop Dis. 2021 Apr 1;15(4):e0009308. doi: 10.1371/journal.pntd.0009308. eCollection 2021 Apr. PLoS Negl Trop Dis. 2021. PMID: 33793555 Free PMC article.
Zika virus infection in pregnant rhesus macaques causes placental dysfunction and immunopathology.
Hirsch AJ, Roberts VHJ, Grigsby PL, Haese N, Schabel MC, Wang X, Lo JO, Liu Z, Kroenke CD, Smith JL, Kelleher M, Broeckel R, Kreklywich CN, Parkins CJ, Denton M, Smith P, DeFilippis V, Messer W, Nelson JA, Hennebold JD, Grafe M, Colgin L, Lewis A, Ducore R, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Moses AV, Morgan TK, Frias AE, Streblow DN. Hirsch AJ, et al. Among authors: broeckel r. Nat Commun. 2018 Jan 17;9(1):263. doi: 10.1038/s41467-017-02499-9. Nat Commun. 2018. PMID: 29343712 Free PMC article.
Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs.
Broeckel R, Sarkar S, May NA, Totonchy J, Kreklywich CN, Smith P, Graves L, DeFilippis VR, Heise MT, Morrison TE, Moorman N, Streblow DN. Broeckel R, et al. Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02325-18. doi: 10.1128/AAC.02325-18. Print 2019 Apr. Antimicrob Agents Chemother. 2019. PMID: 30917980 Free PMC article.
Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.
Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN. Hirsch AJ, et al. Among authors: broeckel rm. PLoS Pathog. 2017 Apr 5;13(4):e1006317. doi: 10.1371/journal.ppat.1006317. eCollection 2017 Apr. PLoS Pathog. 2017. PMID: 28380070 Free PMC article.
21 results