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Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques.
Broeckel R, Fox JM, Haese N, Kreklywich CN, Sukulpovi-Petty S, Legasse A, Smith PP, Denton M, Corvey C, Krishnan S, Colgin LMA, Ducore RM, Lewis AD, Axthelm MK, Mandron M, Cortez P, Rothblatt J, Rao E, Focken I, Carter K, Sapparapau G, Crowe JE Jr, Diamond MS, Streblow DN. Broeckel R, et al. Among authors: fox jm. PLoS Negl Trop Dis. 2017 Jun 19;11(6):e0005637. doi: 10.1371/journal.pntd.0005637. eCollection 2017 Jun. PLoS Negl Trop Dis. 2017. PMID: 28628616 Free PMC article.
Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes.
Pal P, Fox JM, Hawman DW, Huang YJ, Messaoudi I, Kreklywich C, Denton M, Legasse AW, Smith PP, Johnson S, Axthelm MK, Vanlandingham DL, Streblow DN, Higgs S, Morrison TE, Diamond MS. Pal P, et al. Among authors: fox jm. J Virol. 2014 Aug;88(15):8213-26. doi: 10.1128/JVI.01032-14. Epub 2014 May 14. J Virol. 2014. PMID: 24829346 Free PMC article.
Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus.
Smith SA, Silva LA, Fox JM, Flyak AI, Kose N, Sapparapu G, Khomandiak S, Ashbrook AW, Kahle KM, Fong RH, Swayne S, Doranz BJ, McGee CE, Heise MT, Pal P, Brien JD, Austin SK, Diamond MS, Dermody TS, Crowe JE Jr. Smith SA, et al. Among authors: fox jm. Cell Host Microbe. 2015 Jul 8;18(1):86-95. doi: 10.1016/j.chom.2015.06.009. Cell Host Microbe. 2015. PMID: 26159721 Free PMC article.
Neutralizing Monoclonal Antibodies Block Chikungunya Virus Entry and Release by Targeting an Epitope Critical to Viral Pathogenesis.
Jin J, Liss NM, Chen DH, Liao M, Fox JM, Shimak RM, Fong RH, Chafets D, Bakkour S, Keating S, Fomin ME, Muench MO, Sherman MB, Doranz BJ, Diamond MS, Simmons G. Jin J, et al. Among authors: fox jm. Cell Rep. 2015 Dec 22;13(11):2553-2564. doi: 10.1016/j.celrep.2015.11.043. Epub 2015 Dec 10. Cell Rep. 2015. PMID: 26686638 Free PMC article.
Pathogenic Chikungunya Virus Evades B Cell Responses to Establish Persistence.
Hawman DW, Fox JM, Ashbrook AW, May NA, Schroeder KMS, Torres RM, Crowe JE Jr, Dermody TS, Diamond MS, Morrison TE. Hawman DW, et al. Among authors: fox jm. Cell Rep. 2016 Aug 2;16(5):1326-1338. doi: 10.1016/j.celrep.2016.06.076. Epub 2016 Jul 21. Cell Rep. 2016. PMID: 27452455 Free PMC article.
Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice.
Sapparapu G, Fernandez E, Kose N, Bin Cao, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS, Crowe JE. Sapparapu G, et al. Among authors: fox jm. Nature. 2016 Dec 15;540(7633):443-447. doi: 10.1038/nature20564. Epub 2016 Nov 7. Nature. 2016. PMID: 27819683 Free PMC article.
Modified mRNA Vaccines Protect against Zika Virus Infection.
Richner JM, Himansu S, Dowd KA, Butler SL, Salazar V, Fox JM, Julander JG, Tang WW, Shresta S, Pierson TC, Ciaramella G, Diamond MS. Richner JM, et al. Among authors: fox jm. Cell. 2017 Mar 9;168(6):1114-1125.e10. doi: 10.1016/j.cell.2017.02.017. Epub 2017 Feb 17. Cell. 2017. PMID: 28222903 Free PMC article.
425 results