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Therapeutic administration of a recombinant human monoclonal antibody reduces the severity of chikungunya virus disease in rhesus macaques.
Broeckel R, Fox JM, Haese N, Kreklywich CN, Sukulpovi-Petty S, Legasse A, Smith PP, Denton M, Corvey C, Krishnan S, Colgin LMA, Ducore RM, Lewis AD, Axthelm MK, Mandron M, Cortez P, Rothblatt J, Rao E, Focken I, Carter K, Sapparapau G, Crowe JE Jr, Diamond MS, Streblow DN. Broeckel R, et al. Among authors: smith pp. PLoS Negl Trop Dis. 2017 Jun 19;11(6):e0005637. doi: 10.1371/journal.pntd.0005637. eCollection 2017 Jun. PLoS Negl Trop Dis. 2017. PMID: 28628616 Free PMC article.
Chikungunya viruses that escape monoclonal antibody therapy are clinically attenuated, stable, and not purified in mosquitoes.
Pal P, Fox JM, Hawman DW, Huang YJ, Messaoudi I, Kreklywich C, Denton M, Legasse AW, Smith PP, Johnson S, Axthelm MK, Vanlandingham DL, Streblow DN, Higgs S, Morrison TE, Diamond MS. Pal P, et al. Among authors: smith pp. J Virol. 2014 Aug;88(15):8213-26. doi: 10.1128/JVI.01032-14. Epub 2014 May 14. J Virol. 2014. PMID: 24829346 Free PMC article.
Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.
Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN. Hirsch AJ, et al. Among authors: smith pp, smith jl. PLoS Pathog. 2017 Mar 9;13(3):e1006219. doi: 10.1371/journal.ppat.1006219. eCollection 2017 Mar. PLoS Pathog. 2017. PMID: 28278237 Free PMC article.
Correction: Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues.
Hirsch AJ, Smith JL, Haese NN, Broeckel RM, Parkins CJ, Kreklywich C, DeFilippis VR, Denton M, Smith PP, Messer WB, Colgin LM, Ducore RM, Grigsby PL, Hennebold JD, Swanson T, Legasse AW, Axthelm MK, MacAllister R, Wiley CA, Nelson JA, Streblow DN. Hirsch AJ, et al. Among authors: smith pp, smith jl. PLoS Pathog. 2017 Apr 5;13(4):e1006317. doi: 10.1371/journal.ppat.1006317. eCollection 2017 Apr. PLoS Pathog. 2017. PMID: 28380070 Free PMC article.
146 results