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Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells.
Wiśniewska A, Niemira M, Jagiełło K, Potęga A, Swist M, Henderson C, Skwarska A, Augustin E, Konopa J, Mazerska Z. Wiśniewska A, et al. Among authors: augustin e. Biochem Pharmacol. 2012 Jul 1;84(1):30-42. doi: 10.1016/j.bcp.2012.03.013. Epub 2012 Apr 6. Biochem Pharmacol. 2012. PMID: 22484277
Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use.
Pawlowska M, Chu R, Fedejko-Kap B, Augustin E, Mazerska Z, Radominska-Pandya A, Chambers TC. Pawlowska M, et al. Among authors: augustin e. Drug Metab Dispos. 2013 Feb;41(2):414-21. doi: 10.1124/dmd.112.047811. Epub 2012 Nov 16. Drug Metab Dispos. 2013. PMID: 23160818 Free PMC article.
81 results