Hu T - Search Results

1

Mutation in the FGFR1 tyrosine kinase domain or inactivation of PTEN is associated with acquired resistance to FGFR inhibitors in FGFR1-driven leukemia/lymphomas.

Cowell JK, Qin H, Hu T, Wu Q, Bhole A, Ren M. Cowell JK, et al. Among authors: hu t. Int J Cancer. 2017 Nov 1;141(9):1822-1829. doi: 10.1002/ijc.30848. Epub 2017 Jul 28. Int J Cancer. 2017. PMID: 28646488 Free PMC article.

2

The miR-17/92 cluster is involved in the molecular etiology of the SCLL syndrome driven by the BCR-FGFR1 chimeric kinase.

Hu T, Chong Y, Qin H, Kitamura E, Chang CS, Silva J, Ren M, Cowell JK. Hu T, et al. Oncogene. 2018 Apr;37(14):1926-1938. doi: 10.1038/s41388-017-0091-1. Epub 2018 Jan 25. Oncogene. 2018. PMID: 29367757 Free PMC article.

3

FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome.

Hu T, Wu Q, Chong Y, Qin H, Poole CJ, van Riggelen J, Ren M, Cowell JK. Hu T, et al. Leukemia. 2018 Nov;32(11):2363-2373. doi: 10.1038/s41375-018-0124-y. Epub 2018 Apr 2. Leukemia. 2018. PMID: 29720732 Free PMC article.

4

miR-339 Promotes Development of Stem Cell Leukemia/Lymphoma Syndrome via Downregulation of the BCL2L11 and BAX Proapoptotic Genes.

Hu T, Chong Y, Lu S, Wang R, Qin H, Silva J, Kitamura E, Chang CS, Hawthorn L, Cowell JK. Hu T, et al. Cancer Res. 2018 Jul 1;78(13):3522-3531. doi: 10.1158/0008-5472.CAN-17-4049. Epub 2018 May 7. Cancer Res. 2018. PMID: 29735550 Free PMC article.

5

Loss of the BCR-FGFR1 GEF Domain Suppresses RHOA Activation and Enhances B-Lymphomagenesis in Mice.

Hu T, Chong Y, Lu S, Qin H, Ren M, Savage NM, Chang CS, Cowell JK. Hu T, et al. Cancer Res. 2019 Jan 1;79(1):114-124. doi: 10.1158/0008-5472.CAN-18-1889. Epub 2018 Nov 9. Cancer Res. 2019. PMID: 30413411 Free PMC article.

6

Distinct signaling programs associated with progression of FGFR1 driven leukemia in a mouse model of stem cell leukemia lymphoma syndrome.

Silva J, Chang CS, Hu T, Qin H, Kitamura E, Hawthorn L, Ren M, Cowell JK. Silva J, et al. Among authors: hu t. Genomics. 2019 Dec;111(6):1566-1573. doi: 10.1016/j.ygeno.2018.10.015. Epub 2018 Nov 12. Genomics. 2019. PMID: 30439482 Free article.

7

Rac1/2 activation promotes FGFR1 driven leukemogenesis in stem cell leukemia/lymphoma syndrome.

Hu T, Chong Y, Lu S, McGuinness M, Williams DA, Cowell JK. Hu T, et al. Haematologica. 2020 Jan 31;105(2):e68-e71. doi: 10.3324/haematol.2018.208058. Print 2020. Haematologica. 2020. PMID: 31221776 Free PMC article. No abstract available.

8

Critical individual roles of the BCR and FGFR1 kinase domains in BCR-FGFR1-driven stem cell leukemia/lymphoma syndrome.

Chong Y, Liu Y, Lu S, Cai B, Qin H, Chang CS, Ren M, Cowell JK, Hu T. Chong Y, et al. Among authors: hu t. Int J Cancer. 2020 Apr 15;146(8):2243-2254. doi: 10.1002/ijc.32665. Epub 2019 Oct 10. Int J Cancer. 2020. PMID: 31525277

9

DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis.

Hu T, Chong Y, Cai B, Liu Y, Lu S, Cowell JK. Hu T, et al. J Biol Chem. 2019 Nov 29;294(48):18122-18130. doi: 10.1074/jbc.RA119.010144. Epub 2019 Oct 18. J Biol Chem. 2019. PMID: 31628193 Free PMC article.

10

Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome.

Liu Y, Cai B, Chong Y, Zhang H, Kemp CA, Lu S, Chang CS, Ren M, Cowell JK, Hu T. Liu Y, et al. Among authors: hu t. Cell Death Dis. 2020 Oct 20;11(10):884. doi: 10.1038/s41419-020-03098-1. Cell Death Dis. 2020. PMID: 33082322 Free PMC article.

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