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Early activation of fibroblasts is required for kidney repair and regeneration after injury.
Zhou D, Fu H, Liu S, Zhang L, Xiao L, Bastacky SI, Liu Y. Zhou D, et al. FASEB J. 2019 Nov;33(11):12576-12587. doi: 10.1096/fj.201900651RR. Epub 2019 Aug 28. FASEB J. 2019. PMID: 31461626 Free PMC article.
They rapidly entered the cell cycle with Ki-67-positive staining, which started at 1 h and peaked at 12 h after IRI, whereas tubular cell proliferation peaked at 3 d. The trigger for such an early activation of fibroblasts was identified as sonic hedgehog (Shh), which was …
They rapidly entered the cell cycle with Ki-67-positive staining, which started at 1 h and peaked at 12 h after IRI, whereas tubular cell pr …
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