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Adenosine Monophosphate Binding Stabilizes the KTN Domain of the Shewanella denitrificans Kef Potassium Efflux System.
Pliotas C, Grayer SC, Ekkerman S, Chan AKN, Healy J, Marius P, Bartlett W, Khan A, Cortopassi WA, Chandler SA, Rasmussen T, Benesch JLP, Paton RS, Claridge TDW, Miller S, Booth IR, Naismith JH, Conway SJ. Pliotas C, et al. Among authors: benesch jlp. Biochemistry. 2017 Aug 15;56(32):4219-4234. doi: 10.1021/acs.biochem.7b00300. Epub 2017 Aug 4. Biochemistry. 2017. PMID: 28656748 Free PMC article.
Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure determination, table of crystallographic data, table of crystallographic parameters and refinement statistics, figures showing binding mode and distances, procedures for mass spectrometry measurements, differential scanning fluorimetry measurements, stopped-flow measurements and other kinetics measurements. See DOI: 10.1039/c4sc01752hClick here for additional data file.
Brem J, Struwe WB, Rydzik AM, Tarhonskaya H, Pfeffer I, Flashman E, van Berkel SS, Spencer J, Claridge TD, McDonough MA, Benesch JL, Schofield CJ. Brem J, et al. Chem Sci. 2015 Feb 19;6(2):956-963. doi: 10.1039/c4sc01752h. Epub 2014 Nov 4. Chem Sci. 2015. PMID: 25717359 Free PMC article.
Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7.
Gerken PA, Wolstenhulme JR, Tumber A, Hatch SB, Zhang Y, Müller S, Chandler SA, Mair B, Li F, Nijman SMB, Konietzny R, Szommer T, Yapp C, Fedorov O, Benesch JLP, Vedadi M, Kessler BM, Kawamura A, Brennan PE, Smith MD. Gerken PA, et al. Among authors: benesch jlp. Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15555-15559. doi: 10.1002/anie.201706788. Epub 2017 Nov 7. Angew Chem Int Ed Engl. 2017. PMID: 28976073 Free PMC article.
Mass spectrometry beyond the native state.
Chandler SA, Benesch JL. Chandler SA, et al. Curr Opin Chem Biol. 2018 Feb;42:130-137. doi: 10.1016/j.cbpa.2017.11.019. Epub 2017 Dec 27. Curr Opin Chem Biol. 2018. PMID: 29288996 Review.
Origin of complexity in haemoglobin evolution.
Pillai AS, Chandler SA, Liu Y, Signore AV, Cortez-Romero CR, Benesch JLP, Laganowsky A, Storz JF, Hochberg GKA, Thornton JW. Pillai AS, et al. Among authors: benesch jlp. Nature. 2020 May;581(7809):480-485. doi: 10.1038/s41586-020-2292-y. Epub 2020 May 20. Nature. 2020. PMID: 32461643 Free PMC article.
C-terminal interactions mediate the quaternary dynamics of αB-crystallin.
Hilton GR, Hochberg GK, Laganowsky A, McGinnigle SI, Baldwin AJ, Benesch JL. Hilton GR, et al. Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20110405. doi: 10.1098/rstb.2011.0405. Print 2013 May 5. Philos Trans R Soc Lond B Biol Sci. 2013. PMID: 23530258 Free PMC article.
122 results