Horrocks MH - Search Results

1

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species.

Iljina M, Hong L, Horrocks MH, Ludtmann MH, Choi ML, Hughes CD, Ruggeri FS, Guilliams T, Buell AK, Lee JE, Gandhi S, Lee SF, Bryant CE, Vendruscolo M, Knowles TPJ, Dobson CM, De Genst E, Klenerman D. Iljina M, et al. Among authors: horrocks mh. BMC Biol. 2017 Jul 3;15(1):57. doi: 10.1186/s12915-017-0390-6. BMC Biol. 2017. PMID: 28673288 Free PMC article.

2

Single molecule fluorescence under conditions of fast flow.

Horrocks MH, Li H, Shim JU, Ranasinghe RT, Clarke RW, Huck WT, Abell C, Klenerman D. Horrocks MH, et al. Anal Chem. 2012 Jan 3;84(1):179-85. doi: 10.1021/ac202313d. Epub 2011 Dec 6. Anal Chem. 2012. PMID: 22147688

3

Ubiquitin chain conformation regulates recognition and activity of interacting proteins.

Ye Y, Blaser G, Horrocks MH, Ruedas-Rama MJ, Ibrahim S, Zhukov AA, Orte A, Klenerman D, Jackson SE, Komander D. Ye Y, et al. Among authors: horrocks mh. Nature. 2012 Dec 13;492(7428):266-70. doi: 10.1038/nature11722. Epub 2012 Dec 2. Nature. 2012. PMID: 23201676 Free PMC article.

4

Single-molecule measurements of transient biomolecular complexes through microfluidic dilution.

Horrocks MH, Rajah L, Jönsson P, Kjaergaard M, Vendruscolo M, Knowles TP, Klenerman D. Horrocks MH, et al. Anal Chem. 2013 Jul 16;85(14):6855-9. doi: 10.1021/ac4010875. Epub 2013 Jun 27. Anal Chem. 2013. PMID: 23782428 Free PMC article.

5

The changing point-spread function: single-molecule-based super-resolution imaging.

Horrocks MH, Palayret M, Klenerman D, Lee SF. Horrocks MH, et al. Histochem Cell Biol. 2014 Jun;141(6):577-85. doi: 10.1007/s00418-014-1186-1. Epub 2014 Feb 11. Histochem Cell Biol. 2014. PMID: 24509806 Review.

6

Bayesian inference of accurate population sizes and FRET efficiencies from single diffusing biomolecules.

Murphy RR, Danezis G, Horrocks MH, Jackson SE, Klenerman D. Murphy RR, et al. Among authors: horrocks mh. Anal Chem. 2014 Sep 2;86(17):8603-12. doi: 10.1021/ac501188r. Epub 2014 Aug 18. Anal Chem. 2014. PMID: 25105347

7

Lipid peroxidation is essential for α-synuclein-induced cell death.

Angelova PR, Horrocks MH, Klenerman D, Gandhi S, Abramov AY, Shchepinov MS. Angelova PR, et al. Among authors: horrocks mh. J Neurochem. 2015 May;133(4):582-9. doi: 10.1111/jnc.13024. Epub 2015 Mar 1. J Neurochem. 2015. PMID: 25580849 Free PMC article.

8

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.

Shammas SL, Garcia GA, Kumar S, Kjaergaard M, Horrocks MH, Shivji N, Mandelkow E, Knowles TP, Mandelkow E, Klenerman D. Shammas SL, et al. Among authors: horrocks mh. Nat Commun. 2015 Apr 30;6:7025. doi: 10.1038/ncomms8025. Nat Commun. 2015. PMID: 25926130 Free PMC article.

9

Aggregated α-synuclein and complex I deficiency: exploration of their relationship in differentiated neurons.

Reeve AK, Ludtmann MH, Angelova PR, Simcox EM, Horrocks MH, Klenerman D, Gandhi S, Turnbull DM, Abramov AY. Reeve AK, et al. Among authors: horrocks mh. Cell Death Dis. 2015 Jul 16;6(7):e1820. doi: 10.1038/cddis.2015.166. Cell Death Dis. 2015. PMID: 26181201 Free PMC article.

10

Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers.

Horrocks MH, Tosatto L, Dear AJ, Garcia GA, Iljina M, Cremades N, Dalla Serra M, Knowles TP, Dobson CM, Klenerman D. Horrocks MH, et al. Anal Chem. 2015 Sep 1;87(17):8818-26. doi: 10.1021/acs.analchem.5b01811. Epub 2015 Aug 14. Anal Chem. 2015. PMID: 26258431

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