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Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.
Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. Fang X, et al. Among authors: ma x. J Clin Invest. 2017 Aug 1;127(8):3189-3200. doi: 10.1172/JCI94310. Epub 2017 Jul 24. J Clin Invest. 2017. PMID: 28737513 Free PMC article.
P209L mutation in Bag3 does not cause cardiomyopathy in mice.
Fang X, Bogomolovas J, Zhou PS, Mu Y, Ma X, Chen Z, Zhang L, Zhu M, Veevers J, Ouyang K, Chen J. Fang X, et al. Among authors: ma x. Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H392-H399. doi: 10.1152/ajpheart.00714.2018. Epub 2018 Nov 30. Am J Physiol Heart Circ Physiol. 2019. PMID: 30499714 Free PMC article.
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