Hadden MK - Search Results

1

Synthesis and evaluation of vitamin D3 analogues with C-11 modifications as inhibitors of Hedgehog signaling.

Maschinot CA, Hadden MK. Maschinot CA, et al. Among authors: hadden mk. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4011-4014. doi: 10.1016/j.bmcl.2017.07.060. Epub 2017 Jul 24. Bioorg Med Chem Lett. 2017. PMID: 28780161

2

Synthesis and evaluation of Hsp90 inhibitors that contain the 1,4-naphthoquinone scaffold.

Hadden MK, Hill SA, Davenport J, Matts RL, Blagg BS. Hadden MK, et al. Bioorg Med Chem. 2009 Jan 15;17(2):634-40. doi: 10.1016/j.bmc.2008.11.064. Epub 2008 Dec 3. Bioorg Med Chem. 2009. PMID: 19101151 Free PMC article.

3

Comparison of N-terminal modifications on neurotensin(8-13) analogues correlates peptide stability but not binding affinity with in vivo efficacy.

Orwig KS, Lassetter MR, Hadden MK, Dix TA. Orwig KS, et al. Among authors: hadden mk. J Med Chem. 2009 Apr 9;52(7):1803-13. doi: 10.1021/jm801072v. J Med Chem. 2009. PMID: 19290594

4

Probing the structural requirements for vitamin D3 inhibition of the hedgehog signaling pathway.

DeBerardinis AM, Banerjee U, Miller M, Lemieux S, Hadden MK. DeBerardinis AM, et al. Among authors: hadden mk. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4859-63. doi: 10.1016/j.bmcl.2012.05.037. Epub 2012 May 23. Bioorg Med Chem Lett. 2012. PMID: 22687748

5

Hedgehog pathway inhibitors: a patent review (2009--present).

Hadden MK. Hadden MK. Expert Opin Ther Pat. 2013 Mar;23(3):345-61. doi: 10.1517/13543776.2013.757304. Epub 2013 Jan 8. Expert Opin Ther Pat. 2013. PMID: 23294277 Review.

6

Analogues of the Inhoffen-Lythgoe diol with anti-proliferative activity.

DeBerardinis AM, Lemieux S, Hadden MK. DeBerardinis AM, et al. Among authors: hadden mk. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5367-70. doi: 10.1016/j.bmcl.2013.07.054. Epub 2013 Jul 31. Bioorg Med Chem Lett. 2013. PMID: 23972439

7

Hedgehog pathway agonism: therapeutic potential and small-molecule development.

Hadden MK. Hadden MK. ChemMedChem. 2014 Jan;9(1):27-37. doi: 10.1002/cmdc.201300358. Epub 2013 Nov 7. ChemMedChem. 2014. PMID: 24203435 Review.

8

Structure-activity relationships for vitamin D3-based aromatic a-ring analogues as hedgehog pathway inhibitors.

Deberardinis AM, Madden DJ, Banerjee U, Sail V, Raccuia DS, De Carlo D, Lemieux SM, Meares A, Hadden MK. Deberardinis AM, et al. Among authors: hadden mk. J Med Chem. 2014 May 8;57(9):3724-36. doi: 10.1021/jm401812d. Epub 2014 Apr 28. J Med Chem. 2014. PMID: 24730984

9

Recent advances in the design of Hedgehog pathway inhibitors for the treatment of malignancies.

Banerjee U, Hadden MK. Banerjee U, et al. Among authors: hadden mk. Expert Opin Drug Discov. 2014 Jul;9(7):751-71. doi: 10.1517/17460441.2014.920817. Epub 2014 May 22. Expert Opin Drug Discov. 2014. PMID: 24850423 Review.

10

Structure-activity relationships for side chain oxysterol agonists of the hedgehog signaling pathway.

Corman A, DeBerardinis AM, Hadden MK. Corman A, et al. Among authors: hadden mk. ACS Med Chem Lett. 2012 Aug 28;3(10):828-33. doi: 10.1021/ml300192k. eCollection 2012 Oct 11. ACS Med Chem Lett. 2012. PMID: 24900386 Free PMC article.

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