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Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction.
Alvarez RA, Miller MP, Hahn SA, Galley JC, Bauer E, Bachman T, Hu J, Sembrat J, Goncharov D, Mora AL, Rojas M, Goncharova E, Straub AC. Alvarez RA, et al. Among authors: straub ac. Am J Respir Cell Mol Biol. 2017 Dec;57(6):733-744. doi: 10.1165/rcmb.2016-0418OC. Am J Respir Cell Mol Biol. 2017. PMID: 28800253 Free PMC article.
Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.
Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE. Straub AC, et al. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2594-600. doi: 10.1161/ATVBAHA.114.303974. Epub 2014 Oct 2. Arterioscler Thromb Vasc Biol. 2014. PMID: 25278292 Free PMC article.
Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability.
Rahaman MM, Reinders FG, Koes D, Nguyen AT, Mutchler SM, Sparacino-Watkins C, Alvarez RA, Miller MP, Cheng D, Chen BB, Jackson EK, Camacho CJ, Straub AC. Rahaman MM, et al. Among authors: straub ac. J Biol Chem. 2015 Jul 3;290(27):16861-72. doi: 10.1074/jbc.M114.629964. Epub 2015 May 22. J Biol Chem. 2015. PMID: 26001785 Free PMC article.
TSP1-CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction.
Rogers NM, Sharifi-Sanjani M, Yao M, Ghimire K, Bienes-Martinez R, Mutchler SM, Knupp HE, Baust J, Novelli EM, Ross M, St Croix C, Kutten JC, Czajka CA, Sembrat JC, Rojas M, Labrousse-Arias D, Bachman TN, Vanderpool RR, Zuckerbraun BS, Champion HC, Mora AL, Straub AC, Bilonick RA, Calzada MJ, Isenberg JS. Rogers NM, et al. Among authors: straub ac. Cardiovasc Res. 2017 Jan;113(1):15-29. doi: 10.1093/cvr/cvw218. Epub 2016 Oct 13. Cardiovasc Res. 2017. PMID: 27742621 Free PMC article.
Nitric oxide: what's new to NO?
Ghimire K, Altmann HM, Straub AC, Isenberg JS. Ghimire K, et al. Among authors: straub ac. Am J Physiol Cell Physiol. 2017 Mar 1;312(3):C254-C262. doi: 10.1152/ajpcell.00315.2016. Epub 2016 Dec 14. Am J Physiol Cell Physiol. 2017. PMID: 27974299 Free PMC article. Review.
Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling.
Rahaman MM, Nguyen AT, Miller MP, Hahn SA, Sparacino-Watkins C, Jobbagy S, Carew NT, Cantu-Medellin N, Wood KC, Baty CJ, Schopfer FJ, Kelley EE, Gladwin MT, Martin E, Straub AC. Rahaman MM, et al. Among authors: straub ac. Circ Res. 2017 Jul 7;121(2):137-148. doi: 10.1161/CIRCRESAHA.117.310705. Epub 2017 Jun 5. Circ Res. 2017. PMID: 28584062 Free PMC article.
Redox Control of Vascular Function.
Galley JC, Straub AC. Galley JC, et al. Among authors: straub ac. Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):e178-e184. doi: 10.1161/ATVBAHA.117.309945. Arterioscler Thromb Vasc Biol. 2017. PMID: 29162599 Free PMC article. Review. No abstract available.
97 results