Shah DK - Search Results

1

Measurement and Mathematical Characterization of Cell-Level Pharmacokinetics of Antibody-Drug Conjugates: A Case Study with Trastuzumab-vc-MMAE.

Singh AP, Shah DK. Singh AP, et al. Among authors: shah dk. Drug Metab Dispos. 2017 Nov;45(11):1120-1132. doi: 10.1124/dmd.117.076414. Epub 2017 Aug 18. Drug Metab Dispos. 2017. PMID: 28821484 Free PMC article.

2

A priori prediction of tumor payload concentrations: preclinical case study with an auristatin-based anti-5T4 antibody-drug conjugate.

Shah DK, King LE, Han X, Wentland JA, Zhang Y, Lucas J, Haddish-Berhane N, Betts A, Leal M. Shah DK, et al. AAPS J. 2014 May;16(3):452-63. doi: 10.1208/s12248-014-9576-9. Epub 2014 Mar 1. AAPS J. 2014. PMID: 24578215 Free PMC article.

3

Application of Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Antibody-Drug Conjugate Development.

Singh AP, Shin YG, Shah DK. Singh AP, et al. Among authors: shah dk. Pharm Res. 2015 Nov;32(11):3508-25. doi: 10.1007/s11095-015-1626-1. Epub 2015 Feb 11. Pharm Res. 2015. PMID: 25666843 Review.

4

Integration of bioanalytical measurements using PK-PD modeling and simulation: implications for antibody-drug conjugate development.

Khot A, Sharma S, Shah DK. Khot A, et al. Among authors: shah dk. Bioanalysis. 2015;7(13):1633-48. doi: 10.4155/bio.15.85. Bioanalysis. 2015. PMID: 26226312 Review.

5

Evolution of Antibody-Drug Conjugate Tumor Disposition Model to Predict Preclinical Tumor Pharmacokinetics of Trastuzumab-Emtansine (T-DM1).

Singh AP, Maass KF, Betts AM, Wittrup KD, Kulkarni C, King LE, Khot A, Shah DK. Singh AP, et al. Among authors: shah dk. AAPS J. 2016 Jul;18(4):861-75. doi: 10.1208/s12248-016-9904-3. Epub 2016 Mar 30. AAPS J. 2016. PMID: 27029797 Free PMC article.

6

Quantitative characterization of in vitro bystander effect of antibody-drug conjugates.

Singh AP, Sharma S, Shah DK. Singh AP, et al. Among authors: shah dk. J Pharmacokinet Pharmacodyn. 2016 Dec;43(6):567-582. doi: 10.1007/s10928-016-9495-8. Epub 2016 Sep 26. J Pharmacokinet Pharmacodyn. 2016. PMID: 27670282 Free PMC article.

7

Application of a PK-PD Modeling and Simulation-Based Strategy for Clinical Translation of Antibody-Drug Conjugates: a Case Study with Trastuzumab Emtansine (T-DM1).

Singh AP, Shah DK. Singh AP, et al. Among authors: shah dk. AAPS J. 2017 Jul;19(4):1054-1070. doi: 10.1208/s12248-017-0071-y. Epub 2017 Apr 3. AAPS J. 2017. PMID: 28374319 Free PMC article.

8

Development of a Translational Physiologically Based Pharmacokinetic Model for Antibody-Drug Conjugates: a Case Study with T-DM1.

Khot A, Tibbitts J, Rock D, Shah DK. Khot A, et al. Among authors: shah dk. AAPS J. 2017 Nov;19(6):1715-1734. doi: 10.1208/s12248-017-0131-3. Epub 2017 Aug 14. AAPS J. 2017. PMID: 28808917 Free PMC article.

9

Establishing in vitro-in vivo correlation for antibody drug conjugate efficacy: a PK/PD modeling approach.

Shah DK, Loganzo F, Haddish-Berhane N, Musto S, Wald HS, Barletta F, Lucas J, Clark T, Hansel S, Betts A. Shah DK, et al. J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):339-349. doi: 10.1007/s10928-018-9577-x. Epub 2018 Feb 8. J Pharmacokinet Pharmacodyn. 2018. PMID: 29423862

10

Antibody pharmacokinetics in rat brain determined using microdialysis.

Chang HY, Morrow K, Bonacquisti E, Zhang W, Shah DK. Chang HY, et al. Among authors: shah dk. MAbs. 2018 Aug/Sep;10(6):843-853. doi: 10.1080/19420862.2018.1473910. Epub 2018 Aug 6. MAbs. 2018. PMID: 29944439 Free PMC article.

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