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Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease.
Temmerman F, Chen F, Libbrecht L, Vander Elst I, Windmolders P, Feng Y, Ni Y, De Smedt H, Nevens F, van Pelt J. Temmerman F, et al. Among authors: de smedt h. World J Gastroenterol. 2017 Aug 14;23(30):5499-5507. doi: 10.3748/wjg.v23.i30.5499. World J Gastroenterol. 2017. PMID: 28852309 Free PMC article.
mTOR-Controlled Autophagy Requires Intracellular Ca(2+) Signaling.
Decuypere JP, Kindt D, Luyten T, Welkenhuyzen K, Missiaen L, De Smedt H, Bultynck G, Parys JB. Decuypere JP, et al. Among authors: de smedt h. PLoS One. 2013;8(4):e61020. doi: 10.1371/journal.pone.0061020. Epub 2013 Apr 2. PLoS One. 2013. PMID: 23565295 Free PMC article.
Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.
Mekahli D, Decuypere JP, Sammels E, Welkenhuyzen K, Schoeber J, Audrezet MP, Corvelyn A, Dechênes G, Ong AC, Wilmer MJ, van den Heuvel L, Bultynck G, Parys JB, Missiaen L, Levtchenko E, De Smedt H. Mekahli D, et al. Among authors: de smedt h. Pflugers Arch. 2014 Aug;466(8):1591-604. doi: 10.1007/s00424-013-1394-x. Epub 2013 Nov 6. Pflugers Arch. 2014. PMID: 24193408
Polycystins and cellular Ca2+ signaling.
Mekahli D, Parys JB, Bultynck G, Missiaen L, De Smedt H. Mekahli D, et al. Among authors: de smedt h. Cell Mol Life Sci. 2013 Aug;70(15):2697-712. doi: 10.1007/s00018-012-1188-x. Epub 2012 Oct 18. Cell Mol Life Sci. 2013. PMID: 23076254 Free PMC article. Review.
The IP(3) receptor-mitochondria connection in apoptosis and autophagy.
Decuypere JP, Monaco G, Bultynck G, Missiaen L, De Smedt H, Parys JB. Decuypere JP, et al. Among authors: de smedt h. Biochim Biophys Acta. 2011 May;1813(5):1003-13. doi: 10.1016/j.bbamcr.2010.11.023. Epub 2010 Dec 10. Biochim Biophys Acta. 2011. PMID: 21146562 Free article. Review.
The role of calmodulin for inositol 1,4,5-trisphosphate receptor function.
Nadif Kasri N, Bultynck G, Sienaert I, Callewaert G, Erneux C, Missiaen L, Parys JB, De Smedt H. Nadif Kasri N, et al. Among authors: de smedt h. Biochim Biophys Acta. 2002 Nov 4;1600(1-2):19-31. doi: 10.1016/s1570-9639(02)00440-5. Biochim Biophys Acta. 2002. PMID: 12445455 Review.
243 results