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Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.
Bagdany M, Veit G, Fukuda R, Avramescu RG, Okiyoneda T, Baaklini I, Singh J, Sovak G, Xu H, Apaja PM, Sattin S, Beitel LK, Roldan A, Colombo G, Balch W, Young JC, Lukacs GL. Bagdany M, et al. Among authors: young jc. Nat Commun. 2017 Aug 30;8(1):398. doi: 10.1038/s41467-017-00444-4. Nat Commun. 2017. PMID: 28855508 Free PMC article.
Functional divergence between co-chaperones of Hsc70.
Tzankov S, Wong MJ, Shi K, Nassif C, Young JC. Tzankov S, et al. Among authors: young jc. J Biol Chem. 2008 Oct 3;283(40):27100-9. doi: 10.1074/jbc.M803923200. Epub 2008 Aug 6. J Biol Chem. 2008. PMID: 18684711 Free PMC article.
Hsp40 chaperones promote degradation of the HERG potassium channel.
Walker VE, Wong MJ, Atanasiu R, Hantouche C, Young JC, Shrier A. Walker VE, et al. Among authors: young jc. J Biol Chem. 2010 Jan 29;285(5):3319-29. doi: 10.1074/jbc.M109.024000. Epub 2009 Nov 25. J Biol Chem. 2010. PMID: 19940115 Free PMC article.
Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.
Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G. Rodina A, et al. Among authors: young jc. Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14. Chem Biol. 2013. PMID: 24239008 Free PMC article.
hERG quality control and the long QT syndrome.
Foo B, Williamson B, Young JC, Lukacs G, Shrier A. Foo B, et al. Among authors: young jc. J Physiol. 2016 May 1;594(9):2469-81. doi: 10.1113/JP270531. Epub 2016 Feb 9. J Physiol. 2016. PMID: 26718903 Free PMC article. Review.
406 results