Dawadi S - Search Results

1

Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma.

Okon A, Han J, Dawadi S, Demosthenous C, Aldrich CC, Gupta M, Wagner CR. Okon A, et al. Among authors: dawadi s. J Med Chem. 2017 Oct 12;60(19):8131-8144. doi: 10.1021/acs.jmedchem.7b00916. Epub 2017 Sep 20. J Med Chem. 2017. PMID: 28858511

2

Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis.

Nelson KM, Viswanathan K, Dawadi S, Duckworth BP, Boshoff HI, Barry CE 3rd, Aldrich CC. Nelson KM, et al. Among authors: dawadi s. J Med Chem. 2015 Jul 23;58(14):5459-75. doi: 10.1021/acs.jmedchem.5b00391. Epub 2015 Jul 9. J Med Chem. 2015. PMID: 26110337 Free PMC article.

3

Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis.

Dawadi S, Kawamura S, Rubenstein A, Remmel R, Aldrich CC. Dawadi S, et al. Bioorg Med Chem. 2016 Mar 15;24(6):1314-21. doi: 10.1016/j.bmc.2016.02.002. Epub 2016 Feb 3. Bioorg Med Chem. 2016. PMID: 26875934 Free PMC article.

4

Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.

Liu F, Dawadi S, Maize KM, Dai R, Park SW, Schnappinger D, Finzel BC, Aldrich CC. Liu F, et al. Among authors: dawadi s. J Med Chem. 2017 Jul 13;60(13):5507-5520. doi: 10.1021/acs.jmedchem.7b00189. Epub 2017 Jun 22. J Med Chem. 2017. PMID: 28594172 Free PMC article.

5

Conformationally Constrained Cinnolinone Nucleoside Analogues as Siderophore Biosynthesis Inhibitors for Tuberculosis.

Dawadi S, Boshoff HIM, Park SW, Schnappinger D, Aldrich CC. Dawadi S, et al. ACS Med Chem Lett. 2018 Mar 16;9(4):386-391. doi: 10.1021/acsmedchemlett.8b00090. eCollection 2018 Apr 12. ACS Med Chem Lett. 2018. PMID: 29670706 Free PMC article.

6

Investigation and conformational analysis of fluorinated nucleoside antibiotics targeting siderophore biosynthesis.

Dawadi S, Viswanathan K, Boshoff HI, Barry CE 3rd, Aldrich CC. Dawadi S, et al. J Org Chem. 2015 May 15;80(10):4835-50. doi: 10.1021/acs.joc.5b00550. Epub 2015 Apr 30. J Org Chem. 2015. PMID: 25916415 Free PMC article.

7

2-Aryl-8-aza-3-deazaadenosine analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis.

Krajczyk A, Zeidler J, Januszczyk P, Dawadi S, Boshoff HI, Barry CE 3rd, Ostrowski T, Aldrich CC. Krajczyk A, et al. Among authors: dawadi s. Bioorg Med Chem. 2016 Jul 15;24(14):3133-43. doi: 10.1016/j.bmc.2016.05.037. Epub 2016 May 20. Bioorg Med Chem. 2016. PMID: 27265685 Free PMC article.

8

Synthesis and Analysis of Bacterial Folate Metabolism Intermediates and Antifolates.

Dawadi S, Kordus SL, Baughn AD, Aldrich CC. Dawadi S, et al. Org Lett. 2017 Oct 6;19(19):5220-5223. doi: 10.1021/acs.orglett.7b02487. Epub 2017 Sep 19. Org Lett. 2017. PMID: 28926267

9

Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification.

Bockman MR, Engelhart CA, Dawadi S, Larson P, Tiwari D, Ferguson DM, Schnappinger D, Aldrich CC. Bockman MR, et al. Among authors: dawadi s. ACS Infect Dis. 2018 Jul 13;4(7):1102-1113. doi: 10.1021/acsinfecdis.8b00038. Epub 2018 Apr 17. ACS Infect Dis. 2018. PMID: 29663798

10

Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole.

Minato Y, Dawadi S, Kordus SL, Sivanandam A, Aldrich CC, Baughn AD. Minato Y, et al. Among authors: dawadi s. Nat Commun. 2018 Mar 8;9(1):1003. doi: 10.1038/s41467-018-03447-x. Nat Commun. 2018. PMID: 29520101 Free PMC article.

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