Wagner CR - Search Results

1

Anchimerically Activated ProTides as Inhibitors of Cap-Dependent Translation and Inducers of Chemosensitization in Mantle Cell Lymphoma.

Okon A, Han J, Dawadi S, Demosthenous C, Aldrich CC, Gupta M, Wagner CR. Okon A, et al. Among authors: wagner cr. J Med Chem. 2017 Oct 12;60(19):8131-8144. doi: 10.1021/acs.jmedchem.7b00916. Epub 2017 Sep 20. J Med Chem. 2017. PMID: 28858511

2

Synthesis and biological activity of aromatic amino acid phosphoramidates of 5-fluoro-2'-deoxyuridine and 1-beta-arabinofuranosylcytosine: evidence of phosphoramidase activity.

Abraham TW, Kalman TI, McIntee EJ, Wagner CR. Abraham TW, et al. Among authors: wagner cr. J Med Chem. 1996 Nov 8;39(23):4569-75. doi: 10.1021/jm9603680. J Med Chem. 1996. PMID: 8917645

3

Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP.

Ghosh P, Park C, Peterson MS, Bitterman PB, Polunovsky VA, Wagner CR. Ghosh P, et al. Among authors: wagner cr. Bioorg Med Chem Lett. 2005 Apr 15;15(8):2177-80. doi: 10.1016/j.bmcl.2005.01.080. Bioorg Med Chem Lett. 2005. PMID: 15808492

4

Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP.

Jia Y, Chiu TL, Amin EA, Polunovsky V, Bitterman PB, Wagner CR. Jia Y, et al. Among authors: wagner cr. Eur J Med Chem. 2010 Apr;45(4):1304-13. doi: 10.1016/j.ejmech.2009.11.054. Epub 2009 Dec 6. Eur J Med Chem. 2010. PMID: 20060622 Free PMC article.

5

Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target.

Jia Y, Polunovsky V, Bitterman PB, Wagner CR. Jia Y, et al. Among authors: wagner cr. Med Res Rev. 2012 Jul;32(4):786-814. doi: 10.1002/med.21260. Epub 2012 Apr 11. Med Res Rev. 2012. PMID: 22495651 Free PMC article. Review.

6

Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells.

Chen EZ, Jacobson BA, Patel MR, Okon AM, Li S, Xiong K, Vaidya AJ, Bitterman PB, Wagner CR, Kratzke RA. Chen EZ, et al. Among authors: wagner cr. Invest New Drugs. 2014 Aug;32(4):598-603. doi: 10.1007/s10637-014-0076-7. Epub 2014 Apr 9. Invest New Drugs. 2014. PMID: 24711125

7

Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E.

Smith KA, Zhou B, Avdulov S, Benyumov A, Peterson M, Liu Y, Okon A, Hergert P, Braziunas J, Wagner CR, Borok Z, Bitterman PB. Smith KA, et al. Among authors: wagner cr. Sci Rep. 2015 Dec 18;5:18233. doi: 10.1038/srep18233. Sci Rep. 2015. PMID: 26678431 Free PMC article.

8

Anchimerically Activatable Antiviral ProTides.

Okon A, Matos de Souza MR, Shah R, Amorim R, da Costa LJ, Wagner CR. Okon A, et al. Among authors: wagner cr. ACS Med Chem Lett. 2017 Aug 14;8(9):958-962. doi: 10.1021/acsmedchemlett.7b00277. eCollection 2017 Sep 14. ACS Med Chem Lett. 2017. PMID: 28947944 Free PMC article.

9

Induction of the p53 Tumor Suppressor in Cancer Cells through Inhibition of Cap-Dependent Translation.

Harris BRE, Wang D, Zhang Y, Ferrari M, Okon A, Cleary MP, Wagner CR, Yang DQ. Harris BRE, et al. Among authors: wagner cr. Mol Cell Biol. 2018 Apr 30;38(10):e00367-17. doi: 10.1128/MCB.00367-17. Print 2018 May 15. Mol Cell Biol. 2018. PMID: 29483299 Free PMC article.

10

Repression of oncogenic cap-mediated translation by 4Ei-10 diminishes proliferation, enhances chemosensitivity and alters expression of malignancy-related proteins in mesothelioma.

Ahmad Z, Jacobson BA, McDonald MW, Vattendahl Vidal N, Vattendahl Vidal G, Chen S, Dillenburg M, Okon AM, Patel MR, Wagner CR, Kratzke RA. Ahmad Z, et al. Among authors: wagner cr. Cancer Chemother Pharmacol. 2020 Feb;85(2):425-432. doi: 10.1007/s00280-020-04029-9. Epub 2020 Jan 23. Cancer Chemother Pharmacol. 2020. PMID: 31974652

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