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Alizarine derivatives as new dual inhibitors of the HIV-1 reverse transcriptase-associated DNA polymerase and RNase H activities effective also on the RNase H activity of non-nucleoside resistant reverse transcriptases.
Esposito F, Kharlamova T, Distinto S, Zinzula L, Cheng YC, Dutschman G, Floris G, Markt P, Corona A, Tramontano E. Esposito F, et al. Among authors: cheng yc. FEBS J. 2011 May;278(9):1444-57. doi: 10.1111/j.1742-4658.2011.08057.x. Epub 2011 Mar 16. FEBS J. 2011. PMID: 21348941 Free PMC article.
Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance.
Im GJ, Tramontano E, Gonzalez CJ, Cheng YC. Im GJ, et al. Among authors: cheng yc. Biochem Pharmacol. 1993 Dec 14;46(12):2307-13. doi: 10.1016/0006-2952(93)90622-4. Biochem Pharmacol. 1993. PMID: 7506027 Free article.
A single conservative amino acid substitution in the reverse transcriptase of human immunodeficiency virus-1 confers resistance to (+)-(5S)-4,5,6,7-tetrahydro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5, 1- jk][1,4]benzodiazepin-2(1H)-thione (TIBO R82150).
Mellors JW, Im GJ, Tramontano E, Winkler SR, Medina DJ, Dutschman GE, Bazmi HZ, Piras G, Gonzalez CJ, Cheng YC. Mellors JW, et al. Among authors: cheng yc. Mol Pharmacol. 1993 Jan;43(1):11-6. Mol Pharmacol. 1993. PMID: 7678690
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
Yang G, Paintsil E, Dutschman GE, Grill SP, Wang CJ, Wang J, Tanaka H, Hamasaki T, Baba M, Cheng YC. Yang G, et al. Among authors: cheng yc. Antimicrob Agents Chemother. 2009 Nov;53(11):4640-6. doi: 10.1128/AAC.00686-09. Epub 2009 Aug 24. Antimicrob Agents Chemother. 2009. PMID: 19704131 Free PMC article.
1,542 results