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Page 1
A limb-girdle muscular dystrophy 2I model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies.
Serafini PR, Feyder MJ, Hightower RM, Garcia-Perez D, Vieira NM, Lek A, Gibbs DE, Moukha-Chafiq O, Augelli-Szafran CE, Kawahara G, Widrick JJ, Kunkel LM, Alexander MS. Serafini PR, et al. Among authors: hightower rm. JCI Insight. 2018 Sep 20;3(18):e120493. doi: 10.1172/jci.insight.120493. eCollection 2018 Sep 20. JCI Insight. 2018. PMID: 30232282 Free PMC article.
Selective serotonin reuptake inhibitors ameliorate MEGF10 myopathy.
Saha M, Rizzo SA, Ramanathan M, Hightower RM, Santostefano KE, Terada N, Finkel RS, Berg JS, Chahin N, Pacak CA, Wagner RE, Alexander MS, Draper I, Kang PB. Saha M, et al. Among authors: hightower rm. Hum Mol Genet. 2019 Jul 15;28(14):2365-2377. doi: 10.1093/hmg/ddz064. Hum Mol Genet. 2019. PMID: 31267131 Free PMC article.
The SINE Compound KPT-350 Blocks Dystrophic Pathologies in DMD Zebrafish and Mice.
Hightower RM, Reid AL, Gibbs DE, Wang Y, Widrick JJ, Kunkel LM, Kastenschmidt JM, Villalta SA, van Groen T, Chang H, Gornisiewicz S, Landesman Y, Tamir S, Alexander MS. Hightower RM, et al. Mol Ther. 2020 Jan 8;28(1):189-201. doi: 10.1016/j.ymthe.2019.08.016. Epub 2019 Sep 3. Mol Ther. 2020. PMID: 31628052 Free PMC article.
miR-486 is essential for muscle function and suppresses a dystrophic transcriptome.
Samani A, Hightower RM, Reid AL, English KG, Lopez MA, Doyle JS, Conklin MJ, Schneider DA, Bamman MM, Widrick JJ, Crossman DK, Xie M, Jee D, Lai EC, Alexander MS. Samani A, et al. Among authors: hightower rm. Life Sci Alliance. 2022 May 5;5(9):e202101215. doi: 10.26508/lsa.202101215. Print 2022 Sep. Life Sci Alliance. 2022. PMID: 35512829 Free PMC article.