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Nanoparticle-mediated lysosomal reacidification restores mitochondrial turnover and function in β cells under lipotoxicity.
Assali EA, Shlomo D, Zeng J, Taddeo EP, Trudeau KM, Erion KA, Colby AH, Grinstaff MW, Liesa M, Las G, Shirihai OS. Assali EA, et al. Among authors: zeng j. FASEB J. 2019 Mar;33(3):4154-4165. doi: 10.1096/fj.201801292R. Epub 2018 Dec 14. FASEB J. 2019. PMID: 30550357 Free PMC article.
Therefore, our results indicate that mitochondrial dysfunction is downstream of lysosomal alkalization under lipotoxic conditions and that recovery of lysosomal acidity is sufficient to restore the bioenergetic defects.-Assali, E. A., Shlomo, D., Zeng, J., Taddeo, E …
Therefore, our results indicate that mitochondrial dysfunction is downstream of lysosomal alkalization under lipotoxic conditions and that r …
IRGM1 links mitochondrial quality control to autoimmunity.
Rai P, Janardhan KS, Meacham J, Madenspacher JH, Lin WC, Karmaus PWF, Martinez J, Li QZ, Yan M, Zeng J, Grinstaff MW, Shirihai OS, Taylor GA, Fessler MB. Rai P, et al. Among authors: zeng j. Nat Immunol. 2021 Mar;22(3):312-321. doi: 10.1038/s41590-020-00859-0. Epub 2021 Jan 28. Nat Immunol. 2021. PMID: 33510463 Free PMC article.
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