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The pancreatic tumor microenvironment drives changes in miRNA expression that promote cytokine production and inhibit migration by the tumor associated stroma.
Han S, Gonzalo DH, Feely M, Delitto D, Behrns KE, Beveridge M, Zhang D, Thomas R, Trevino JG, Schmittgen TD, Hughes SJ. Han S, et al. Among authors: thomas r. Oncotarget. 2016 Jul 20;8(33):54054-54067. doi: 10.18632/oncotarget.10722. eCollection 2017 Aug 15. Oncotarget. 2016. PMID: 28903323 Free PMC article.
Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.
Delitto D, Perez C, Han S, Gonzalo DH, Pham K, Knowlton AE, Graves CL, Behrns KE, Moldawer LL, Thomas RM, Liu C, George TJ Jr, Trevino JG, Wallet SM, Hughes SJ. Delitto D, et al. Cancer Immunol Immunother. 2015 Dec;64(12):1553-63. doi: 10.1007/s00262-015-1760-y. Epub 2015 Sep 30. Cancer Immunol Immunother. 2015. PMID: 26423423 Free PMC article.
Isolation of Pancreatic Cancer Cells from a Patient-Derived Xenograft Model Allows for Practical Expansion and Preserved Heterogeneity in Culture.
Pham K, Delitto D, Knowlton AE, Hartlage ER, Madhavan R, Gonzalo DH, Thomas RM, Behrns KE, George TJ Jr, Hughes SJ, Wallet SM, Liu C, Trevino JG. Pham K, et al. Among authors: thomas rm. Am J Pathol. 2016 Jun;186(6):1537-46. doi: 10.1016/j.ajpath.2016.02.009. Epub 2016 Apr 18. Am J Pathol. 2016. PMID: 27102771 Free PMC article.
Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.
Delitto D, Delitto AE, DiVita BB, Pham K, Han S, Hartlage ER, Newby BN, Gerber MH, Behrns KE, Moldawer LL, Thomas RM, George TJ Jr, Brusko TM, Mathews CE, Liu C, Trevino JG, Hughes SJ, Wallet SM. Delitto D, et al. Among authors: thomas rm. Cancer Res. 2017 Feb 1;77(3):672-683. doi: 10.1158/0008-5472.CAN-16-1765. Epub 2016 Nov 18. Cancer Res. 2017. PMID: 27864347 Free PMC article.
8,487 results