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Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport.
Ruderisch N, Schlatter D, Kuglstatter A, Guba W, Huber S, Cusulin C, Benz J, Rufer AC, Hoernschemeyer J, Schweitzer C, Bülau T, Gärtner A, Hoffmann E, Niewoehner J, Patsch C, Baumann K, Loetscher H, Kitas E, Freskgård PO. Ruderisch N, et al. Among authors: loetscher h. EBioMedicine. 2017 Oct;24:76-92. doi: 10.1016/j.ebiom.2017.09.004. Epub 2017 Sep 7. EBioMedicine. 2017. PMID: 28923680 Free PMC article.
Cargo Delivery into the Brain by in vivo identified Transport Peptides.
Urich E, Schmucki R, Ruderisch N, Kitas E, Certa U, Jacobsen H, Schweitzer C, Bergadano A, Ebeling M, Loetscher H, Freskgård PO. Urich E, et al. Among authors: loetscher h. Sci Rep. 2015 Sep 28;5:14104. doi: 10.1038/srep14104. Sci Rep. 2015. PMID: 26411801 Free PMC article.
Gantenerumab: a novel human anti-Aβ antibody demonstrates sustained cerebral amyloid-β binding and elicits cell-mediated removal of human amyloid-β.
Bohrmann B, Baumann K, Benz J, Gerber F, Huber W, Knoflach F, Messer J, Oroszlan K, Rauchenberger R, Richter WF, Rothe C, Urban M, Bardroff M, Winter M, Nordstedt C, Loetscher H. Bohrmann B, et al. Among authors: loetscher h. J Alzheimers Dis. 2012;28(1):49-69. doi: 10.3233/JAD-2011-110977. J Alzheimers Dis. 2012. PMID: 21955818 Free article.
Region-specific permeability of the blood-brain barrier upon pericyte loss.
Villaseñor R, Kuennecke B, Ozmen L, Ammann M, Kugler C, Grüninger F, Loetscher H, Freskgård PO, Collin L. Villaseñor R, et al. Among authors: loetscher h. J Cereb Blood Flow Metab. 2017 Dec;37(12):3683-3694. doi: 10.1177/0271678X17697340. Epub 2017 Mar 1. J Cereb Blood Flow Metab. 2017. PMID: 28273726 Free PMC article.
Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer's Disease.
Borroni E, Bohrmann B, Grueninger F, Prinssen E, Nave S, Loetscher H, Chinta SJ, Rajagopalan S, Rane A, Siddiqui A, Ellenbroek B, Messer J, Pähler A, Andersen JK, Wyler R, Cesura AM. Borroni E, et al. Among authors: loetscher h. J Pharmacol Exp Ther. 2017 Sep;362(3):413-423. doi: 10.1124/jpet.117.241653. Epub 2017 Jun 22. J Pharmacol Exp Ther. 2017. PMID: 28642233
Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab.
Ostrowitzki S, Deptula D, Thurfjell L, Barkhof F, Bohrmann B, Brooks DJ, Klunk WE, Ashford E, Yoo K, Xu ZX, Loetscher H, Santarelli L. Ostrowitzki S, et al. Among authors: loetscher h. Arch Neurol. 2012 Feb;69(2):198-207. doi: 10.1001/archneurol.2011.1538. Epub 2011 Oct 10. Arch Neurol. 2012. PMID: 21987394 Clinical Trial.
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