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463 results

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Page 1
Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant.
Tkachev V, Furlan SN, Watkins B, Hunt DJ, Zheng HB, Panoskaltsis-Mortari A, Betz K, Brown M, Schell JB, Zeleski K, Yu A, Kirby I, Cooley S, Miller JS, Blazar BR, Casson D, Bland-Ward P, Kean LS. Tkachev V, et al. Among authors: watkins b. Sci Transl Med. 2017 Sep 20;9(408):eaan3085. doi: 10.1126/scitranslmed.aan3085. Sci Transl Med. 2017. PMID: 28931653 Free PMC article.
CD8-predominant T-cell CNS infiltration accompanies GVHD in primates and is improved with immunoprophylaxis.
Kaliyaperumal S, Watkins B, Sharma P, Furlan S, Ramakrishnan S, Giver C, Garcia A, Courtney C, Knight H, Strobert E, Elder E, Crenshaw T, Blazar BR, Waller EK, Westmoreland S, Kean LS. Kaliyaperumal S, et al. Among authors: watkins b. Blood. 2014 Mar 20;123(12):1967-9. doi: 10.1182/blood-2014-01-547612. Blood. 2014. PMID: 24652969 Free PMC article. No abstract available.
CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire.
Suessmuth Y, Mukherjee R, Watkins B, Koura DT, Finstermeier K, Desmarais C, Stempora L, Horan JT, Langston A, Qayed M, Khoury HJ, Grizzle A, Cheeseman JA, Conger JA, Robertson J, Garrett A, Kirk AD, Waller EK, Blazar BR, Mehta AK, Robins HS, Kean LS. Suessmuth Y, et al. Among authors: watkins b. Blood. 2015 Jun 18;125(25):3835-50. doi: 10.1182/blood-2015-03-631853. Epub 2015 Apr 7. Blood. 2015. PMID: 25852054 Free PMC article. Clinical Trial.
Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.
Furlan SN, Watkins B, Tkachev V, Flynn R, Cooley S, Ramakrishnan S, Singh K, Giver C, Hamby K, Stempora L, Garrett A, Chen J, Betz KM, Ziegler CG, Tharp GK, Bosinger SE, Promislow DE, Miller JS, Waller EK, Blazar BR, Kean LS. Furlan SN, et al. Among authors: watkins b. Sci Transl Med. 2015 Nov 25;7(315):315ra191. doi: 10.1126/scitranslmed.aad3231. Sci Transl Med. 2015. PMID: 26606970 Free PMC article.
The Knife's Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques.
Zheng HB, Watkins B, Tkachev V, Yu S, Tran D, Furlan S, Zeleski K, Singh K, Hamby K, Hotchkiss C, Lane J, Gumber S, Adams AB, Cendales L, Kirk AD, Kaur A, Blazar BR, Larsen CP, Kean LS. Zheng HB, et al. Among authors: watkins b. Am J Transplant. 2017 Mar;17(3):657-670. doi: 10.1111/ajt.14006. Epub 2016 Sep 19. Am J Transplant. 2017. PMID: 27500470 Free PMC article.
Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells.
Furlan SN, Watkins B, Tkachev V, Cooley S, Panoskaltsis-Mortari A, Betz K, Brown M, Hunt DJ, Schell JB, Zeleski K, Yu A, Giver CR, Waller EK, Miller JS, Blazar BR, Kean LS. Furlan SN, et al. Among authors: watkins b. Blood. 2016 Nov 24;128(21):2568-2579. doi: 10.1182/blood-2016-07-726547. Epub 2016 Oct 6. Blood. 2016. PMID: 27758873 Free PMC article.
Preclinical Testing of Antihuman CD28 Fab' Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease.
Hippen KL, Watkins B, Tkachev V, Lemire AM, Lehnen C, Riddle MJ, Singh K, Panoskaltsis-Mortari A, Vanhove B, Tolar J, Kean LS, Blazar BR. Hippen KL, et al. Among authors: watkins b. Transplantation. 2016 Dec;100(12):2630-2639. doi: 10.1097/TP.0000000000001465. Transplantation. 2016. PMID: 27861291 Free PMC article.
CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates.
Watkins BK, Tkachev V, Furlan SN, Hunt DJ, Betz K, Yu A, Brown M, Poirier N, Zheng HB, Taraseviciute A, Colonna L, Mary C, Blancho G, Soulillou JP, Panoskaltsis-Mortari A, Sharma P, Garcia A, Strobert E, Hamby K, Garrett A, Deane T, Blazar BR, Vanhove B, Kean LS. Watkins BK, et al. J Clin Invest. 2018 Aug 31;128(9):3991-4007. doi: 10.1172/JCI98793. Epub 2018 Aug 13. J Clin Invest. 2018. PMID: 30102255 Free PMC article.
A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors.
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM. Qayed M, et al. Among authors: watkins b. Pediatr Blood Cancer. 2020 Apr;67(4):e28134. doi: 10.1002/pbc.28134. Epub 2019 Dec 25. Pediatr Blood Cancer. 2020. PMID: 31876107 Clinical Trial.
463 results