Lashuel HA - Search Results

1

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths.

Warner JB 4th, Ruff KM, Tan PS, Lemke EA, Pappu RV, Lashuel HA. Warner JB 4th, et al. Among authors: lashuel ha. J Am Chem Soc. 2017 Oct 18;139(41):14456-14469. doi: 10.1021/jacs.7b06659. Epub 2017 Oct 9. J Am Chem Soc. 2017. PMID: 28937758 Free PMC article.

2

Amyloids go genomic: insights regarding the sequence determinants of prion formation from genome-wide studies.

Lashuel HA, Pappu RV. Lashuel HA, et al. Chembiochem. 2009 Aug 17;10(12):1951-4. doi: 10.1002/cbic.200900373. Chembiochem. 2009. PMID: 19598186 Free PMC article. Review.

3

Elucidating the role of C-terminal post-translational modifications using protein semisynthesis strategies: α-synuclein phosphorylation at tyrosine 125.

Hejjaoui M, Butterfield S, Fauvet B, Vercruysse F, Cui J, Dikiy I, Prudent M, Olschewski D, Zhang Y, Eliezer D, Lashuel HA. Hejjaoui M, et al. Among authors: lashuel ha. J Am Chem Soc. 2012 Mar 21;134(11):5196-210. doi: 10.1021/ja210866j. Epub 2012 Mar 13. J Am Chem Soc. 2012. PMID: 22339654 Free PMC article.

4

Discovery of a novel aggregation domain in the huntingtin protein: implications for the mechanisms of Htt aggregation and toxicity.

Wang ZM, Lashuel HA. Wang ZM, et al. Among authors: lashuel ha. Angew Chem Int Ed Engl. 2013 Jan 7;52(2):562-7. doi: 10.1002/anie.201206561. Epub 2012 Nov 12. Angew Chem Int Ed Engl. 2013. PMID: 23148019

5

One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease.

Ansaloni A, Wang ZM, Jeong JS, Ruggeri FS, Dietler G, Lashuel HA. Ansaloni A, et al. Among authors: lashuel ha. Angew Chem Int Ed Engl. 2014 Feb 10;53(7):1928-33. doi: 10.1002/anie.201307510. Epub 2014 Jan 20. Angew Chem Int Ed Engl. 2014. PMID: 24446188

6

Elucidating the Role of Site-Specific Nitration of α-Synuclein in the Pathogenesis of Parkinson's Disease via Protein Semisynthesis and Mutagenesis.

Burai R, Ait-Bouziad N, Chiki A, Lashuel HA. Burai R, et al. Among authors: lashuel ha. J Am Chem Soc. 2015 Apr 22;137(15):5041-52. doi: 10.1021/ja5131726. Epub 2015 Apr 8. J Am Chem Soc. 2015. PMID: 25768729

7

Detection of huntingtin exon 1 phosphorylation by Phos-Tag SDS-PAGE: Predominant phosphorylation on threonine 3 and regulation by IKKβ.

Bustamante MB, Ansaloni A, Pedersen JF, Azzollini L, Cariulo C, Wang ZM, Petricca L, Verani M, Puglisi F, Park H, Lashuel H, Caricasole A. Bustamante MB, et al. Biochem Biophys Res Commun. 2015 Aug 7;463(4):1317-22. doi: 10.1016/j.bbrc.2015.06.116. Epub 2015 Jun 21. Biochem Biophys Res Commun. 2015. PMID: 26106822

8

An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation.

Vieweg S, Ansaloni A, Wang ZM, Warner JB, Lashuel HA. Vieweg S, et al. Among authors: lashuel ha. J Biol Chem. 2016 Jun 3;291(23):12074-86. doi: 10.1074/jbc.M116.713982. Epub 2016 Mar 21. J Biol Chem. 2016. PMID: 27002149 Free PMC article.

9

Nanoscale studies link amyloid maturity with polyglutamine diseases onset.

Ruggeri FS, Vieweg S, Cendrowska U, Longo G, Chiki A, Lashuel HA, Dietler G. Ruggeri FS, et al. Among authors: lashuel ha. Sci Rep. 2016 Aug 8;6:31155. doi: 10.1038/srep31155. Sci Rep. 2016. PMID: 27499269 Free PMC article.

10

Mutant Exon1 Huntingtin Aggregation is Regulated by T3 Phosphorylation-Induced Structural Changes and Crosstalk between T3 Phosphorylation and Acetylation at K6.

Chiki A, DeGuire SM, Ruggeri FS, Sanfelice D, Ansaloni A, Wang ZM, Cendrowska U, Burai R, Vieweg S, Pastore A, Dietler G, Lashuel HA. Chiki A, et al. Among authors: lashuel ha. Angew Chem Int Ed Engl. 2017 May 2;56(19):5202-5207. doi: 10.1002/anie.201611750. Epub 2017 Mar 23. Angew Chem Int Ed Engl. 2017. PMID: 28334491

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