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Editor's Highlight: Complete Attenuation of Mouse Lung Cell Proliferation and Tumorigenicity in CYP2F2 Knockout and CYP2F1 Humanized Mice Exposed to Inhaled Styrene for up to 2 Years Supports a Lack of Human Relevance.
Cruzan G, Bus JS, Banton MI, Sarang SS, Waites R, Layko DB, Raymond J, Dodd D, Andersen ME. Cruzan G, et al. Among authors: bus js. Toxicol Sci. 2017 Oct 1;159(2):413-421. doi: 10.1093/toxsci/kfx141. Toxicol Sci. 2017. PMID: 28962520 Free PMC article.
Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures.
Andersen ME, Cruzan G, Black MB, Pendse SN, Dodd D, Bus JS, Sarang SS, Banton MI, Waites R, McMullen PD. Andersen ME, et al. Among authors: bus js. Toxicol Appl Pharmacol. 2017 Nov 15;335:28-40. doi: 10.1016/j.taap.2017.09.015. Epub 2017 Sep 23. Toxicol Appl Pharmacol. 2017. PMID: 28951217 Free article.
Strain-related differences in mouse lung gene expression over a two-year period of inhalation exposure to styrene: Relevance to human risk assessment.
Andersen ME, Cruzan G, Black MB, Pendse SN, Dodd DE, Bus JS, Sarang SS, Banton MI, Waites R, Layko DB, McMullen PD. Andersen ME, et al. Among authors: bus js. Regul Toxicol Pharmacol. 2018 Jul;96:153-166. doi: 10.1016/j.yrtph.2018.05.011. Epub 2018 May 17. Regul Toxicol Pharmacol. 2018. PMID: 29777725 Free article.
Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver.
Andersen ME, Black MB, Campbell JL, Pendse SN, Clewell HJ III, Pottenger LH, Bus JS, Dodd DE, Kemp DC, McMullen PD. Andersen ME, et al. Among authors: bus js. Toxicol Appl Pharmacol. 2017 Oct 1;332:149-158. doi: 10.1016/j.taap.2017.04.002. Epub 2017 Apr 7. Toxicol Appl Pharmacol. 2017. PMID: 28392392 Free article.
125 results