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mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors.
Malone CF, Emerson C, Ingraham R, Barbosa W, Guerra S, Yoon H, Liu LL, Michor F, Haigis M, Macleod KF, Maertens O, Cichowski K. Malone CF, et al. Among authors: macleod kf. Cancer Discov. 2017 Dec;7(12):1450-1463. doi: 10.1158/2159-8290.CD-17-0177. Epub 2017 Sep 29. Cancer Discov. 2017. PMID: 28963352 Free PMC article.
Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.
De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K. De Raedt T, et al. Among authors: macleod kf. Cancer Cell. 2011 Sep 13;20(3):400-13. doi: 10.1016/j.ccr.2011.08.014. Cancer Cell. 2011. PMID: 21907929 Free PMC article.
Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.
Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA. Humpton TJ, et al. Among authors: macleod kf. Cancer Discov. 2019 Sep;9(9):1268-1287. doi: 10.1158/2159-8290.CD-18-1409. Epub 2019 Jul 1. Cancer Discov. 2019. PMID: 31263025 Free PMC article.
Expanding perspectives on the significance of mitophagy in cancer.
Drake LE, Springer MZ, Poole LP, Kim CJ, Macleod KF. Drake LE, et al. Among authors: macleod kf. Semin Cancer Biol. 2017 Dec;47:110-124. doi: 10.1016/j.semcancer.2017.04.008. Epub 2017 Apr 24. Semin Cancer Biol. 2017. PMID: 28450176 Free PMC article. Review.
In Brief: Mitophagy: mechanisms and role in human disease.
Springer MZ, Macleod KF. Springer MZ, et al. Among authors: macleod kf. J Pathol. 2016 Nov;240(3):253-255. doi: 10.1002/path.4774. Epub 2016 Sep 29. J Pathol. 2016. PMID: 27453450 Free PMC article.
Autophagy in cancer metastasis.
Mowers EE, Sharifi MN, Macleod KF. Mowers EE, et al. Among authors: macleod kf. Oncogene. 2017 Mar 23;36(12):1619-1630. doi: 10.1038/onc.2016.333. Epub 2016 Sep 5. Oncogene. 2017. PMID: 27593926 Free PMC article. Review.
67 results