Abell C - Search Results

1

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach.

Mugumbate G, Mendes V, Blaszczyk M, Sabbah M, Papadatos G, Lelievre J, Ballell L, Barros D, Abell C, Blundell TL, Overington JP. Mugumbate G, et al. Among authors: abell c. Front Pharmacol. 2017 Sep 26;8:681. doi: 10.3389/fphar.2017.00681. eCollection 2017. Front Pharmacol. 2017. PMID: 29018348 Free PMC article.

2

Crystal structure of aspartate decarboxylase at 2.2 A resolution provides evidence for an ester in protein self-processing.

Albert A, Dhanaraj V, Genschel U, Khan G, Ramjee MK, Pulido R, Sibanda BL, von Delft F, Witty M, Blundell TL, Smith AG, Abell C. Albert A, et al. Among authors: abell c. Nat Struct Biol. 1998 Apr;5(4):289-93. doi: 10.1038/nsb0498-289. Nat Struct Biol. 1998. PMID: 9546220

3

The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily.

von Delft F, Lewendon A, Dhanaraj V, Blundell TL, Abell C, Smith AG. von Delft F, et al. Among authors: abell c. Structure. 2001 May 9;9(5):439-50. doi: 10.1016/s0969-2126(01)00604-9. Structure. 2001. PMID: 11377204 Free article.

4

Crystal structure of Escherichia coli ketopantoate reductase at 1.7 A resolution and insight into the enzyme mechanism.

Matak-Vinković D, Vinković M, Saldanha SA, Ashurst JL, von Delft F, Inoue T, Miguel RN, Smith AG, Blundell TL, Abell C. Matak-Vinković D, et al. Among authors: abell c. Biochemistry. 2001 Dec 4;40(48):14493-500. doi: 10.1021/bi011020w. Biochemistry. 2001. PMID: 11724562

5

High-throughput crystallography for lead discovery in drug design.

Blundell TL, Jhoti H, Abell C. Blundell TL, et al. Among authors: abell c. Nat Rev Drug Discov. 2002 Jan;1(1):45-54. doi: 10.1038/nrd706. Nat Rev Drug Discov. 2002. PMID: 12119609 Review.

6

Comparative analysis of the Escherichia coli ketopantoate hydroxymethyltransferase crystal structure confirms that it is a member of the (betaalpha)8 phosphoenolpyruvate/pyruvate superfamily.

Schmitzberger F, Smith AG, Abell C, Blundell TL. Schmitzberger F, et al. Among authors: abell c. J Bacteriol. 2003 Jul;185(14):4163-71. doi: 10.1128/JB.185.14.4163-4171.2003. J Bacteriol. 2003. PMID: 12837791 Free PMC article.

7

Structure of E. coli ketopantoate hydroxymethyl transferase complexed with ketopantoate and Mg2+, solved by locating 160 selenomethionine sites.

von Delft F, Inoue T, Saldanha SA, Ottenhof HH, Schmitzberger F, Birch LM, Dhanaraj V, Witty M, Smith AG, Blundell TL, Abell C. von Delft F, et al. Among authors: abell c. Structure. 2003 Aug;11(8):985-96. doi: 10.1016/s0969-2126(03)00158-8. Structure. 2003. PMID: 12906829 Free article.

8

The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound.

Lobley CM, Ciulli A, Whitney HM, Williams G, Smith AG, Abell C, Blundell TL. Lobley CM, et al. Among authors: abell c. Biochemistry. 2005 Jun 28;44(25):8930-9. doi: 10.1021/bi0502036. Biochemistry. 2005. PMID: 15966718

9

Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate.

Kerbarh O, Chirgadze DY, Blundell TL, Abell C. Kerbarh O, et al. Among authors: abell c. J Mol Biol. 2006 Mar 24;357(2):524-34. doi: 10.1016/j.jmb.2005.12.078. Epub 2006 Jan 11. J Mol Biol. 2006. PMID: 16434053

10

Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.

Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Ciulli A, et al. Among authors: abell c. J Med Chem. 2006 Aug 10;49(16):4992-5000. doi: 10.1021/jm060490r. J Med Chem. 2006. PMID: 16884311

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