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Melflufen - a peptidase-potentiated alkylating agent in clinical trials.
Wickström M, Nygren P, Larsson R, Harmenberg J, Lindberg J, Sjöberg P, Jerling M, Lehmann F, Richardson P, Anderson K, Chauhan D, Gullbo J. Wickström M, et al. Among authors: gullbo j. Oncotarget. 2017 Jun 8;8(39):66641-66655. doi: 10.18632/oncotarget.18420. eCollection 2017 Sep 12. Oncotarget. 2017. PMID: 29029544 Free PMC article. Review.
Preclinical activity of melflufen (J1) in ovarian cancer.
Carlier C, Strese S, Viktorsson K, Velander E, Nygren P, Uustalu M, Juntti T, Lewensohn R, Larsson R, Spira J, De Vlieghere E, Ceelen WP, Gullbo J. Carlier C, et al. Among authors: gullbo j. Oncotarget. 2016 Sep 13;7(37):59322-59335. doi: 10.18632/oncotarget.11163. Oncotarget. 2016. PMID: 27528037 Free PMC article.
Aminopeptidase N (CD13) as a target for cancer chemotherapy.
Wickström M, Larsson R, Nygren P, Gullbo J. Wickström M, et al. Among authors: gullbo j. Cancer Sci. 2011 Mar;102(3):501-8. doi: 10.1111/j.1349-7006.2010.01826.x. Epub 2011 Jan 30. Cancer Sci. 2011. PMID: 21205077 Free PMC article. Review.
First-in-human, phase I/IIa clinical study of the peptidase potentiated alkylator melflufen administered every three weeks to patients with advanced solid tumor malignancies.
Berglund Å, Ullén A, Lisyanskaya A, Orlov S, Hagberg H, Tholander B, Lewensohn R, Nygren P, Spira J, Harmenberg J, Jerling M, Alvfors C, Ringbom M, Nordström E, Söderlind K, Gullbo J. Berglund Å, et al. Among authors: gullbo j. Invest New Drugs. 2015 Dec;33(6):1232-41. doi: 10.1007/s10637-015-0299-2. Epub 2015 Nov 10. Invest New Drugs. 2015. PMID: 26553306 Clinical Trial.
In vitro and in vivo activity of melflufen (J1)in lymphoma.
Delforoush M, Strese S, Wickström M, Larsson R, Enblad G, Gullbo J. Delforoush M, et al. Among authors: gullbo j. BMC Cancer. 2016 Apr 4;16:263. doi: 10.1186/s12885-016-2299-9. BMC Cancer. 2016. PMID: 27044263 Free PMC article.
87 results