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A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover.
Deyaert E, Wauters L, Guaitoli G, Konijnenberg A, Leemans M, Terheyden S, Petrovic A, Gallardo R, Nederveen-Schippers LM, Athanasopoulos PS, Pots H, Van Haastert PJM, Sobott F, Gloeckner CJ, Efremov R, Kortholt A, Versées W. Deyaert E, et al. Among authors: gallardo r. Nat Commun. 2017 Oct 18;8(1):1008. doi: 10.1038/s41467-017-01103-4. Nat Commun. 2017. PMID: 29044096 Free PMC article.
Structural hot spots for the solubility of globular proteins.
Ganesan A, Siekierska A, Beerten J, Brams M, Van Durme J, De Baets G, Van der Kant R, Gallardo R, Ramakers M, Langenberg T, Wilkinson H, De Smet F, Ulens C, Rousseau F, Schymkowitz J. Ganesan A, et al. Among authors: gallardo r. Nat Commun. 2016 Feb 24;7:10816. doi: 10.1038/ncomms10816. Nat Commun. 2016. PMID: 26905391 Free PMC article.
Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis.
Khodaparast L, Khodaparast L, Gallardo R, Louros NN, Michiels E, Ramakrishnan R, Ramakers M, Claes F, Young L, Shahrooei M, Wilkinson H, Desager M, Mengistu Tadesse W, Nilsson KPR, Hammarström P, Aertsen A, Carpentier S, Van Eldere J, Rousseau F, Schymkowitz J. Khodaparast L, et al. Among authors: gallardo r. Nat Commun. 2018 Feb 28;9(1):866. doi: 10.1038/s41467-018-03131-0. Nat Commun. 2018. PMID: 29491361 Free PMC article.
Local structural preferences in shaping tau amyloid polymorphism.
Louros N, Wilkinson M, Tsaka G, Ramakers M, Morelli C, Garcia T, Gallardo R, D'Haeyer S, Goossens V, Audenaert D, Thal DR, Mackenzie IR, Rademakers R, Ranson NA, Radford SE, Rousseau F, Schymkowitz J. Louros N, et al. Among authors: gallardo r. Nat Commun. 2024 Feb 3;15(1):1028. doi: 10.1038/s41467-024-45429-2. Nat Commun. 2024. PMID: 38310108 Free PMC article.
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors.
Xu J, Reumers J, Couceiro JR, De Smet F, Gallardo R, Rudyak S, Cornelis A, Rozenski J, Zwolinska A, Marine JC, Lambrechts D, Suh YA, Rousseau F, Schymkowitz J. Xu J, et al. Among authors: gallardo r. Nat Chem Biol. 2011 May;7(5):285-95. doi: 10.1038/nchembio.546. Epub 2011 Mar 27. Nat Chem Biol. 2011. PMID: 21445056
Reverse engineering synthetic antiviral amyloids.
Michiels E, Roose K, Gallardo R, Khodaparast L, Khodaparast L, van der Kant R, Siemons M, Houben B, Ramakers M, Wilkinson H, Guerreiro P, Louros N, Kaptein SJF, Ibañez LI, Smet A, Baatsen P, Liu S, Vorberg I, Bormans G, Neyts J, Saelens X, Rousseau F, Schymkowitz J. Michiels E, et al. Among authors: gallardo r. Nat Commun. 2020 Jun 5;11(1):2832. doi: 10.1038/s41467-020-16721-8. Nat Commun. 2020. PMID: 32504029 Free PMC article.
204 results